Cytogenetic correlates of TET2 mutations in 199 patients with myeloproliferative neoplasms Journal Article
| Authors: | Hussein, K.; Abdel-Wahab, O.; Lasho, T. L.; Van Dyke, D. L.; Levine, R. L.; Hanson, C. A.; Pardanani, A.; Tefferi, A. |
| Article Title: | Cytogenetic correlates of TET2 mutations in 199 patients with myeloproliferative neoplasms |
| Abstract: | TET2 is a putative tumor suppressor gene located at chromosome 4q24. TET2 mutations were recently described in several myeloid neoplasms but correlations with cytogenetic findings have not been studied. Among a recently described cohort of patients with myeloproliferative neoplasms (MPN) who underwent TET2 mutation analysis, 199 had information on karyotype at diagnosis or time of TET2 testing: 71 polycythemia vera (PV), 55 primary myelofibrosis (PMF), 43 essential thrombocythemia (ET), 13 post-PV MF, 7 post-ET MF, and 10 blast phase MPN. Forty eight patients (24%) exhibited abnormal karyotype: 15 favorable (sole 20q-, 13q-, or +9), 8 unfavorable (complex karyotype or sole +8), and 25 "other" cytogenetic abnormalities. We found no significant difference either in the incidence or type of cytogenetic abnormalities between TET2 mutated (n = 25) and unmutated (n = 174) cases. Seventy nine patients, including 14 with TET2 mutations, underwent follow-up cytogenetic testing and the findings were again not affected by TET2 mutational status. We conclude that TET2 mutated MPN patients are not cytogenetically different than their TET2 unmutated counterparts. |
| Keywords: | adult; aged; aged, 80 and over; middle aged; myeloproliferative disorders; young adult; dna binding protein; oncoprotein; tet2 protein, human; major clinical study; genetics; mutation; myeloproliferative disorder; dna-binding proteins; proto-oncogene proteins; janus kinase 2; myeloid metaplasia; follow up; letter; incidence; cohort analysis; cytogenetics; tumor suppressor gene; karyotype; karyotyping; polycythemia vera; thrombocythemia; jak2 protein, human; chromosome 4; ten eleven translocation oncogene |
| Journal Title: | American Journal of Hematology |
| Volume: | 85 |
| Issue: | 1 |
| ISSN: | 0361-8609 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2010-01-01 |
| Start Page: | 81 |
| End Page: | 83 |
| Language: | English |
| DOI: | 10.1002/ajh.21562 |
| PUBMED: | 19957346 |
| PROVIDER: | scopus |
| PMCID: | PMC4654625 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "CODEN: AJHED" - "Source: Scopus" |
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