Photochemical approaches to T-cell activation Journal Article
| Author: | Huse, M. |
| Article Title: | Photochemical approaches to T-cell activation |
| Abstract: | Despite decades of intensive research, T-cell activation has remained mysterious because of both the dizzying diversity of antigen recognition and the speed and comprehensiveness of the T-cell-receptor signalling network. Further progress will require new approaches and reagents that provide added levels of control. Photochemistry allows specific biochemical processes to be controlled with light and is well suited to mechanistic studies in complex cellular environments. In recent years, several laboratories have adopted approaches based on photoreactive peptide-major histocompatibility complex reagents in order to study T-cell activation and function with high precision. Here, I review these efforts and outline future directions for this exciting area of research. © 2010 Blackwell Publishing Ltd. |
| Keywords: | signal transduction; protein phosphorylation; review; nonhuman; t cells; t-lymphocytes; animals; t lymphocyte receptor; lymphocyte activation; antigen specificity; protein kinase c; cytoskeleton; antigen presenting cell; t lymphocyte activation; lat protein; photoactivation; dynein adenosine triphosphatase; phospholipase c gamma; photochemistry; calcium transport; calcium signaling; signalling; calcium ion; major histocompatibility antigen; lymphocyte membrane; microbial immunity |
| Journal Title: | Immunologiya |
| Volume: | 130 |
| Issue: | 2 |
| ISSN: | 0206-4952 |
| Publisher: | Meditsina Publishers |
| Date Published: | 2010-06-01 |
| Start Page: | 151 |
| End Page: | 157 |
| Language: | English |
| DOI: | 10.1111/j.1365-2567.2010.03267.x |
| PUBMED: | 20406301 |
| PROVIDER: | scopus |
| PMCID: | PMC2878459 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IMMUA" - "Source: Scopus" |
