Practical management of patients with non-small-cell lung cancer treated with gefitinib Journal Article


Authors: Shah, N. T.; Kris, M. G.; Pao, W.; Tyson, L. B.; Pizzo, B. M.; Heinemann, M. H.; Ben-Porat, L.; Sachs, D. L.; Heelan, R. T.; Miller, V. A.
Article Title: Practical management of patients with non-small-cell lung cancer treated with gefitinib
Abstract: Purpose The use of gefitinib, the first drug approved to inhibit the epidermal growth factor receptor tyrosine kinase, is indicated in patients with non-small-cell lung cancer with tumors progressive after chemotherapy. The unique mechanism of action of this agent leads to distinctive patterns of response and toxicity in persons with lung cancer. Many of the principles of management relevant to gefitinib are distinct from those with conventional cytotoxic drugs. To meet this need, we present practical guidelines on the use of gefitinib in patients with non-small-cell lung cancer. Methods This article reviews gefitinib's indications, dosing, response phenomena, and patterns of relapse in individuals with radiographic response. Results We present our recommendations for the management of rash and diarrhea caused by this agent. Conclusion This information can guide practitioners and help them inform their patients about what to expect when they receive gefitinib.
Keywords: functional assessment; inhibitor; docetaxel; tumors; receptor tyrosine kinase; therapy; mutations; phase-iii trial; randomized-trial; zd1839 iressa
Journal Title: Journal of Clinical Oncology
Volume: 23
Issue: 1
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2005-01-01
Start Page: 165
End Page: 174
Language: English
DOI: 10.1200/jco.2005.04.057
ACCESSION: WOS:000226380600022
PROVIDER: wos
PUBMED: 15557594
Notes: --- - Article - "Source: Wos"
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MSK Authors
  1. Dana L Sachs
    23 Sachs
  2. Vincent Miller
    270 Miller
  3. Mark Kris
    847 Kris
  4. Robert T Heelan
    140 Heelan
  5. Leslie Tyson
    70 Tyson
  6. Barbara Pizzo
    31 Pizzo