Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: The Cancer and Leukemia Group B (study 9730) Journal Article


Authors: Lilenbaum, R. C.; Herndon, J. E.; List, M. A.; Desch, C.; Watson, D. M.; Miller, A. A.; Graziano, S. L.; Perry, M. C.; Saville, W.; Chahinian, P.; Weeks, J. C.; Holland, J. C.; Green, M. R.
Article Title: Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: The Cancer and Leukemia Group B (study 9730)
Abstract: Purpose We compared the efficacy of combination chemotherapy versus single-agent therapy in patients with advanced non-small-cell lung cancer. Patients and Methods A total of 561 eligible patients were randomly assigned to receive paclitaxel alone or in combination with carboplatin. Results The response rate was 17% in the paclitaxel arm and 30% in the carboplatin-paclitaxel. arm (P < .0001). Median failure-free survival was 2.5 months in the paclitaxel arm and 4.6 months in the carboplatin-paclitaxel arm (P = .0002). Median survival times were 6.7 months (95% CI, 5.8 to 7.8) and 8.8 months (95% CI, 8.0 to 9.9), and 1-year survival rates were 32% (95% CI, 27% to 38%), and 37% (95% CI, 32% to 43%), respectively. The overall survival distributions were not statistically different: hazard ratio = 0.91 (95% CI, 0.77 to 1.17; P = .25). Hematological toxicity and nausea were more frequent in the combination arm, but febrile neutropenia and toxic deaths were equally low in both arms. There was no significant survival difference in elderly patients. Performance status 2 patients treated with combination chemotherapy had a better survival rate than those treated with single-agent therapy (P = .019). Conclusion Combination chemotherapy improves response rate and failure-free survival compared with single-agent therapy, but there was no statistically significant difference in the primary end point of overall survival. The results in elderly patients were similar to younger patients. Performance status 2 patients had a superior outcome when treated with combination chemotherapy.
Keywords: survival; cisplatin; ifosfamide; docetaxel; phase-iii trial; randomized-trial; elderly-patients; vinorelbine; regimens
Journal Title: Journal of Clinical Oncology
Volume: 23
Issue: 1
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2005-01-01
Start Page: 190
End Page: 196
Language: English
DOI: 10.1200/jco.2005.07.172
ACCESSION: WOS:000226380600025
PROVIDER: wos
PUBMED: 15625373
Notes: --- - Article; Proceedings Paper - 38th Annual Meeting of the American-Society-of-Clinical-Oncology - MAY 18-21, 2002 - ORLANDO, FL - "Source: Wos"
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  1. Jimmie C B Holland
    228 Holland