Triple-negative breast cancer: Role of the androgen receptor Journal Article
| Authors: | Gucalp, A.; Traina, T. A. |
| Article Title: | Triple-negative breast cancer: Role of the androgen receptor |
| Abstract: | The androgen receptor (AR), a member of the steroid hormone receptor family, is expressed in more than 70% of breast cancers and has been implicated in breast cancer pathogenesis. The role of the AR is of particular interest in patients with estrogen- and progesterone receptor negative and HER2-negative cancers, which represent ∼25% of all breast cancers. The "triple-negative" subset of tumors generally has a more aggressive clinical course and does not benefit from conventional endocrine targeted therapies. However, emerging evidence suggests that the AR may serve as a therapeutic target for a subset of triple-negative breast cancers. Herein, we review the role of the AR in breast cancer tumorigenesis and current progress and future directions in the development of AR-targeted therapies. © 2010 Lippincott Williams & Wilkins, Inc. |
| Keywords: | signal transduction; protein expression; clinical trial; constipation; drug tolerability; review; advanced cancer; cancer growth; diarrhea; drug efficacy; nonhuman; clinical trials as topic; liver dysfunction; drug targeting; gene targeting; breast cancer; gene expression profiling; anemia; protein targeting; nausea; epidermal growth factor receptor 2; gene function; breast neoplasms; abdominal pain; cancer hormone therapy; prostate cancer; androgen receptor; receptor, erbb-2; receptors, estrogen; receptors, progesterone; tumor promotion; bicalutamide; gonadorelin agonist; receptors, androgen; estrogen receptor; progesterone receptor; hormone receptor; breast carcinogenesis; gynecomastia; triple negative breast cancer; triple-negative breast cancer; hirsutism; hormone receptor interaction; mastalgia; ovary polycystic disease |
| Journal Title: | The Cancer Journal |
| Volume: | 16 |
| Issue: | 1 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2010-01-01 |
| Start Page: | 62 |
| End Page: | 65 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e3181ce4ae1 |
| PUBMED: | 20164692 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: CAJOC" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work