Resisting arrest: A switch from angiogenesis to vasculogenesis in recurrent malignant gliomas Journal Article

   

Authors:	Greenfield, J. P.; Cobb, W. S.; Lyden, D.
Article Title:	Resisting arrest: A switch from angiogenesis to vasculogenesis in recurrent malignant gliomas
Abstract:	The cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to disease progression. In this issue of the JCI, Kioi et al. demonstrate that vasculogenesis and angiogenesis potentially play distinct roles in the etiology of primary and recurrent malignant gliomas, suggesting that patient therapy should perhaps be tailored specifically against the predominant vasculature pathway at a given specific stage of gliomagenesis.
Keywords:	immunohistochemistry; signal transduction; bevacizumab; antineoplastic agents; note; temozolomide; brain tumor; brain neoplasms; cell proliferation; tumor associated leukocyte; animals; mice; bone marrow cells; melanoma; neoplasm recurrence, local; gene expression profiling; tumor volume; transforming growth factor beta; gelatinase b; cell line, tumor; angiogenesis; neovascularization, pathologic; skull irradiation; hypoxia; endothelium cell; fibrosarcoma; mice, nude; tumor recurrence; glioblastoma; blood brain barrier; vasculotropin a; tumor cell; transplantation, heterologous; cell movement; bone marrow cell; hematopoietic stem cell; neoplasm transplantation; monocytes; angiopoietin receptor; tumor vascularization; neovascularization (pathology); anti-hiv agents; heterocyclic compounds; vasculotropin receptor 1; whole-body irradiation; stromal cell derived factor 1; chemokine cxcl12; receptors, cxcr4; chemokine receptor cxcr4; antibodies, neutralizing; cd11 antigen; smad4 protein; antigens, cd11b; hypoxia-inducible factor 1
Journal Title:	Journal of Clinical Investigation
Volume:	120
Issue:	3
ISSN:	0021-9738
Publisher:	American Society for Clinical Investigation
Date Published:	2010-03-01
Start Page:	663
End Page:	667
Language:	English
DOI:	10.1172/jci42345
PUBMED:	20179347
PROVIDER:	scopus
PMCID:	PMC2827970
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77949715989&partnerID=40&md5=f7c667532a0047e8aff150e2af0bdc64
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: JCINA" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/4189