Epigenetics on the brain: Modifying chromatin and behaviour Journal Article

  


Author: Goll, M. G.
Article Title: Epigenetics on the brain: Modifying chromatin and behaviour
Abstract: Proper regulation of gene expression is essential for the development and survival of every organism. Epigenetic modifications provide a way for cells to regulate gene expression and to propagate expression states heritably through cell division. Given the brain's complexity, it is not surprising that epigenetic regulation is essential for both normal development and maintenance of homoeostasis of this organ. New data suggest that the role of epigenetic regulation in the brain may extend much further, influencing both the ways neurons organize their networks in response to new experiences and the resultant behaviours. Such studies highlight the relevance of epigenetic regulation for neurodevelopmental and neuropsychiatric disease. © 2010 The Biochemical Society.
Keywords: dna methylation; astrocytes; histone modification; neurodevelopment; rett syndrome
Journal Title: Biochemist
Volume: 32
Issue: 5
ISSN: 0954-982X
Publisher: Portland Press Ltd  
Date Published: 2010-10-01
Start Page: 18
End Page: 20
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77957941968&partnerID=40&md5=7b3cce552976f3f488663964b8febdd2
Notes: --- - "Export Date: 20 April 2011" - "Source: Scopus"