Radical host-specific therapies for TB Journal Article
| Authors: | van Heijst, J. W. J.; Pamer, E. G. |
| Article Title: | Radical host-specific therapies for TB |
| Abstract: | Although proinflammatory cytokines such as TNF are critical for containment of tuberculosis, they can also exacerbate disease when produced at high levels. In this issue of Cell, Roca and Ramakrishnan demonstrate that high TNF production induces reactive oxygen species in infected macrophages, ultimately leading to macrophage necrosis and bacterial dissemination. © 2013 Elsevier Inc. |
| Keywords: | disease course; nonhuman; human immunodeficiency virus infection; phenotype; allele; cell death; gene targeting; genotype; mycobacterium tuberculosis; reactive oxygen metabolite; cytokine production; macrophage; phagosome; granulocyte; tumor necrosis factor; ceramide; cyclophilin d; desipramine; early secretory antigenic target 6; mixed infection; bacterial load; bacterial clearance; tuberculous meningitis; host range; alisporivir; leukotriene a4 hydrolase; necroptosis |
| Journal Title: | Cell |
| Volume: | 153 |
| Issue: | 3 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2013-04-25 |
| Start Page: | 507 |
| End Page: | 508 |
| Language: | English |
| DOI: | 10.1016/j.cell.2013.04.019 |
| PROVIDER: | scopus |
| PUBMED: | 23622234 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 June 2013" - "CODEN: CELLB" - "Source: Scopus" |
