Identification and Characterization of Poorly Differentiated Invasive Carcinomas in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis Journal Article
| Authors: | Hunter, K. E.; Quick, M. L.; Sadanandam, A.; Hanahan, D.; Joyce, J. A. |
| Article Title: | Identification and Characterization of Poorly Differentiated Invasive Carcinomas in a Mouse Model of Pancreatic Neuroendocrine Tumorigenesis |
| Abstract: | Pancreatic neuroendocrine tumors (PanNETs) are a relatively rare but clinically challenging tumor type. In particular, high grade, poorly-differentiated PanNETs have the worst patient prognosis, and the underlying mechanisms of disease are poorly understood. In this study we have identified and characterized a previously undescribed class of poorly differentiated PanNETs in the RIP1-Tag2 mouse model. We found that while the majority of tumors in the RIP1-Tag2 model are well-differentiated insulinomas, a subset of tumors had lost multiple markers of beta-cell differentiation and were highly invasive, leading us to term them poorly differentiated invasive carcinomas (PDICs). In addition, we found that these tumors exhibited a high mitotic index, resembling poorly differentiated (PD)-PanNETs in human patients. Interestingly, we identified expression of Id1, an inhibitor of DNA binding gene, and a regulator of differentiation, specifically in PDIC tumor cells by histological analysis. The identification of PDICs in this mouse model provides a unique opportunity to study the pathology and molecular characteristics of PD-PanNETs. © 2013 Hunter et al. |
| Journal Title: | PLoS ONE |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2013-05-14 |
| Start Page: | e64472 |
| Language: | English |
| DOI: | 10.1371/journal.pone.0064472 |
| PROVIDER: | scopus |
| PMCID: | PMC3653861 |
| PUBMED: | 23691228 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 June 2013" - "Source: Scopus" |
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