Evaluation of response to induction chemotherapy in esophageal cancer: Is barium esophagography or PET-CT useful? Journal Article
| Authors: | Eng, C. W.; Fuqua, J. L.; Grewal, R.; Ilson, D.; Messiah, A. C. D.; Rizk, N.; Tang, L.; Gollub, M. J. |
| Article Title: | Evaluation of response to induction chemotherapy in esophageal cancer: Is barium esophagography or PET-CT useful? |
| Abstract: | Objective: To determine whether sequential barium esophagograms can predict histopathological response to treatment in esophageal cancer. Materials and methods: Two radiologists retrospectively reviewed esophagograms pre- and post- chemotherapy in 32 patients for tumor length decrease of at least 15% and luminal width increase of at least 15%. Positron emission tomography-computed tomography (PET-CT) was reviewed for tumor maximum standardized uptake value (SUVmax) decrease of at least 35%. The reference standard was 90% or more tumor necrosis at histopathologic examination of the excised specimen. Results: Pathologic response ranged from 10% to 100% necrosis. For prediction of tumor response, the sensitivity, specificity, positive and negative predictive values for length ranged from 43.8 to 56.3% and for width from 41.2% to 66.7% and for SUVmax from 47.1% to 53.3%. Conclusion: Performance characteristics for barium esophagograms in our group of patients were similar to PET-CT in predicting tumor response. Both tests were inadequate in predicting tumor response. © 2013 Elsevier Inc. |
| Keywords: | adult; clinical article; treatment outcome; treatment response; aged; retrospective studies; histopathology; cisplatin; chemotherapy; cancer staging; positron emission tomography; sensitivity and specificity; reproducibility of results; progression free survival; computer assisted tomography; multiple cycle treatment; phase 2 clinical trial; antineoplastic combined chemotherapy protocols; camptothecin; diagnostic imaging; retrospective study; irinotecan; computerized tomography; tumors; fluorodeoxyglucose f 18; remission induction; forecasting; contrast media; esophagus cancer; negative predictive value; diseases; esophageal neoplasms; predictive value; esophageal cancer; induction chemotherapy; fluoroscopy; diagnostic test accuracy study; pet-ct; barium; barium sulfate; pathologic response; positron-emission tomography and computed tomography; esophagography; barium esophagography; maximum standardized uptake values; performance characteristics; reference standard |
| Journal Title: | Clinical Imaging |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 0899-7071 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-05-01 |
| Start Page: | 468 |
| End Page: | 474 |
| Language: | English |
| DOI: | 10.1016/j.clinimag.2012.08.003 |
| PROVIDER: | scopus |
| PUBMED: | 23601767 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 June 2013" - "CODEN: CLIME" - "Source: Scopus" |
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