Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival Journal Article
| Authors: | Gabbai, C. B.; Marians, K. J. |
| Article Title: | Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival |
| Abstract: | PriA, a 3′ → 5′ superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity. © 2010 Elsevier B.V. |
| Keywords: | unclassified drug; gene mutation; review; dna replication; protein domain; protein function; protein motif; dna recombination; cell survival; protein binding; enzyme activity; dna; genomic instability; amino acid; dna structure; helicase; adenosine triphosphate; dna binding; multienzyme complexes; dna helicases; recombination; dna-directed dna polymerase; dna replication restart; pria helicase; primosome; recg helicase; replisome; bacteriophage mu |
| Journal Title: | DNA Repair |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1568-7864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-03-02 |
| Start Page: | 202 |
| End Page: | 209 |
| Language: | English |
| DOI: | 10.1016/j.dnarep.2009.12.009 |
| PUBMED: | 20097140 |
| PROVIDER: | scopus |
| PMCID: | PMC2827650 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 20 April 2011" - "CODEN: DRNEA" - "Source: Scopus" |
