Echinacea purpurea aerial extract alters course of influenza infection in mice Journal Article
| Authors: | Fusco, D.; Liu, X.; Savage, C.; Taur, Y.; Xiao, W.; Kennelly, E.; Yuan, J.; Cassileth, B.; Salvatore, M.; Papanicolaou, G. A. |
| Article Title: | Echinacea purpurea aerial extract alters course of influenza infection in mice |
| Abstract: | Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-γ levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity. © 2010. |
| Keywords: | controlled study; disease course; nonhuman; protein blood level; mouse; animals; mice; animal tissue; interleukin 2; interleukin 10; interleukin 1beta; interleukin 4; interleukin 5; interleukin 8; animal experiment; animal model; body weight; weight reduction; mice, inbred c57bl; cytokines; tumor necrosis factor alpha; gamma interferon; drug response; lung; single drug dose; phytotherapy; plant extracts; polysaccharide; echinacea; plant leaf; c57bl 6 mouse; cytokine release; polysaccharides; influenza; interleukin 12; drug isolation; interleukin-10; influenza a virus, h1n1 subtype; echinacea purpurea extract; experimental infection; flower; influenza a (h1n1); lung homogenate; plant stem; virus titration; orthomyxoviridae infections; plant components, aerial; viral load |
| Journal Title: | Vaccine |
| Volume: | 28 |
| Issue: | 23 |
| ISSN: | 0264-410X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-05-21 |
| Start Page: | 3956 |
| End Page: | 3962 |
| Language: | English |
| DOI: | 10.1016/j.vaccine.2010.03.047 |
| PUBMED: | 20382242 |
| PROVIDER: | scopus |
| PMCID: | PMC3016056 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: VACCD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work