CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection Journal Article

   


Authors: Waitz, R.; Fassò, M.; Allison, J. P.
Article Title: CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
Abstract: We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
Keywords: melanoma; prostate cancer; immunity; ctla-4; cryoablation; combination immunotherapy; ipilumimab; spas-1
Journal Title: OncoImmunology
Volume: 1
Issue: 4
ISSN: 2162-4011
Publisher: Landes Bioscience  
Date Published: 2012-07-01
Start Page: 544
End Page: 546
Language: English
DOI: 10.4161/onci.19442
ACCESSION: WOS:000316264200024
PROVIDER: wos
PMCID: PMC3382897
PUBMED: 22754781
Notes: --- - Article - "Source: Wos"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Rebecca Waitz
    13 Waitz
  2. James P Allison
    130 Allison
Related MSK Work