A low postoperative nonstimulated serum thyroglobulin level does not exclude the presence of radioactive iodine avid metastatic foci in intermediate-risk differentiated thyroid cancer patients Journal Article


Authors: Robenshtok, E.; Grewal, R. K.; Fish, S.; Sabra, M.; Tuttle, R. M.
Article Title: A low postoperative nonstimulated serum thyroglobulin level does not exclude the presence of radioactive iodine avid metastatic foci in intermediate-risk differentiated thyroid cancer patients
Abstract: Background: Postsurgical thyrotropin (TSH)-stimulated serum thyroglobulin (Tg) level can be used to predict the likelihood of finding radioactive iodine (RAI) avid metastatic foci on postablation scanning. However, there is little data regarding the predictive value of a nonstimulated postoperative Tg obtained on levothyroxine therapy in patients being considered for recombinant human TSH (rhTSH)-Assisted remnant ablation. Methods: The study included 290 intermediate-risk differentiated thyroid cancer (DTC) patients with a postsurgical nonstimulated Tg<10 ng/mL prior to rhTSH-Assisted remnant ablation. Patients were stratified into four groups based on the postsurgical nonstimulated Tg value: Tg<0.6 ng/mL (n=146), Tg 0.6-0.9 ng/mL (n=76), Tg 1-5 ng/mL (n=51), and Tg>5-10 ng/mL (n=17). RAI avid metastatic foci were identified using post-therapy scanning with SPECT/CT (single photon emission computed tomography). Results: RAI avid metastases were identified in 16% (46/290) of patients, including 12% (17/146) with Tg<0.6 ng/mL, 14% (11/76) with Tg 0.6-0.9 ng/mL, 25% (13/51) with Tg 1-5 ng/mL, and 29% (5/17) with Tg>5-10 ng/mL (p=0.02). While 99% of the RAI avid foci were located in the neck, lung uptake was seen in one patient with Tg<0.6 ng/mL (0.7%, 1/146), one patient with Tg 0.6-0.9 ng/mL (1.3%, 1/76), and 2 patients with Tg>5-10 ng/mL (11%, 2/17 patients). Conclusions: A postoperative nonstimulated Tg<0.6 ng/mL does not exclude identification of RAI avid metastatic foci on postablation SPECT/CT scanning in intermediate-risk DTC patients. Therefore, patient selection for RAI ablation in the intermediate-risk group must be based on an integration of multiple risk factors rather than any single clinicopathologic risk factor. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
Keywords: adult; controlled study; aged; middle aged; cancer surgery; major clinical study; postoperative period; cancer risk; multimodality cancer therapy; outcome assessment; lymph node metastasis; risk factors; medical record review; retrospective study; distant metastasis; iodine 131; iodine radioisotopes; neoplasm metastasis; predictive value of tests; thyroidectomy; thyroid neoplasms; thyroglobulin; cervical lymph node; thyroglobulin blood level; single photon emission computer tomography; cancer scintiscanning; local metastasis; recombinant thyrotropin; predictive value; thyrotropin; tumor ablation; thyrotropin blood level; differentiated thyroid cancer; limit of detection; iodine 123
Journal Title: Thyroid
Volume: 23
Issue: 4
ISSN: 1050-7256
Publisher: Mary Ann Liebert, Inc  
Date Published: 2013-04-01
Start Page: 436
End Page: 442
Language: English
PROVIDER: scopus
PUBMED: 23067402
DOI: 10.1089/thy.2012.0352
DOI/URL:
Notes: --- - "Export Date: 1 May 2013" - "CODEN: THYRE" - ":doi 10.1089/thy.2012.0352" - ": Chemicals/CASiodine 123, 15715-08-9; iodine 131, 10043-66-0, 15124-39-7; recombinant thyrotropin, 194100-83-9; thyroglobulin, 9010-34-8; thyrotropin, 9002-71-5" - "Source: Scopus"
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MSK Authors
  1. Robert M Tuttle
    483 Tuttle
  2. Mona M Sabra
    43 Sabra
  3. Stephanie Anne Fish
    25 Fish