Parathyroid carcinoma: Challenges in diagnosis and treatment Journal Article
| Authors: | Mohebati, A.; Shaha, A.; Shah, J. |
| Article Title: | Parathyroid carcinoma: Challenges in diagnosis and treatment |
| Abstract: | Parathyroid carcinoma is a malignant neoplasm affecting 0.5% to 5.0% of all patients with primary hyperparathyroidism. Since it was first described by De Quervain in 1904 to this day, it continues to defy diagnosis and treatment because of its rarity, overlapping features with benign parathyroid disease, and lack of distinct characteristics. En bloc surgical extirpation of the tumor with clear margins remains the best curative treatment. Although prolonged survival is possible with recurrent or metastatic disease, cure is rarely achievable. Efficacy of adjuvant therapies, such as radiotherapy and chemotherapy, in management of persistent, recurrent, or metastatic disease has been disappointing. Copyright © 2012 Elsevier Inc. All rights reserved. |
| Keywords: | review; hypercalcemia; parathyroid neoplasms; parathyroid tumor |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 26 |
| Issue: | 6 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-12-01 |
| Start Page: | 1221 |
| End Page: | 1238 |
| Language: | English |
| PUBMED: | 23116578 |
| PROVIDER: | scopus |
| DOI: | 10.1016/j.hoc.2012.08.009 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "Source: Scopus" |
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