Adult rhabdomyosarcoma survival improved with treatment on multimodality protocols Journal Article
| Authors: | Gerber, N. K.; Wexler, L. H.; Singer, S.; Alektiar, K. M.; Keohan, M. L.; Shi, W.; Zhang, Z.; Wolden, S. |
| Article Title: | Adult rhabdomyosarcoma survival improved with treatment on multimodality protocols |
| Abstract: | Purpose: Rhabdomyosarcoma (RMS) is a pediatric sarcoma rarely occurring in adults. For unknown reasons, adults with RMS have worse outcomes than do children. Methods and Materials: We analyzed data from all patients who presented to Memorial Sloan-Kettering Cancer Center between 1990 and 2011 with RMS diagnosed at age 16 or older. One hundred forty-eight patients met the study criteria. Ten were excluded for lack of adequate data. Results: The median age was 28 years. The histologic diagnoses were as follows: embryonal 54%, alveolar 33%, pleomorphic 12%, and not otherwise specified 2%. The tumor site was unfavorable in 67% of patients. Thirty-three patients (24%) were at low risk, 61 (44%) at intermediate risk, and 44 (32%) at high risk. Forty-six percent were treated on or according to a prospective RMS protocol. The 5-year rate of overall survival (OS) was 45% for patients with nonmetastatic disease. The failure rates at 5 years for patients with nonmetastatic disease were 34% for local failure and 42% for distant failure. Among patients with nonmetastatic disease (n=94), significant factors associated with OS were histologic diagnosis, site, risk group, age, and protocol treatment. On multivariate analysis, risk group and protocol treatment were significant after adjustment for age. The 5-year OS was 54% for protocol patients versus 36% for nonprotocol patients. Conclusions: Survival in adult patients with nonmetastatic disease was significantly improved for those treated on RMS protocols, most of which are now open to adults. © 2013 Elsevier Inc. All rights reserved. |
| Keywords: | overall survival; tumors; diagnosis; rhabdomyosarcoma; patient treatment; multi variate analysis; diseases; local failure; adult patients; multi-modality; intermediate risks; methods and materials |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 86 |
| Issue: | 1 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-05-01 |
| Start Page: | 58 |
| End Page: | 63 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 23414767 |
| DOI: | 10.1016/j.ijrobp.2012.12.016 |
| PMCID: | PMC3927967 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: IOBPD" - ":doi 10.1016/j.ijrobp.2012.12.016" - "Source: Scopus" |
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