Chimeric Antigen Receptor Therapy for Chronic Lymphocytic Leukemia. What are the Challenges? Journal Article
| Authors: | Davila, M. L.; Brentjens, R. |
| Article Title: | Chimeric Antigen Receptor Therapy for Chronic Lymphocytic Leukemia. What are the Challenges? |
| Abstract: | Chimeric antigen receptor (CAR)-modified T cells targeting CD19 expressed by normal and malignant B cells is a unique therapy for patients with chronic lymphocytic leukemia (CLL); recent results highlight the potential of this therapy for patients with relapsed CLL. Because adoptive transfer of CAR-modified T cells is a novel approach, there are issues for the medical oncologist to consider when evaluating current and future clinical trials for CLL patients. This article reviews the impact of CAR design, T-cell production, T-cell dose, conditioning regimens, and tumor burden at the time of CAR-modified T-cell infusion on the efficacy of this therapy. © 2013 Elsevier Inc.. |
| Keywords: | signal transduction; cancer chemotherapy; treatment response; review; nonhuman; clinical trials as topic; drug megadose; outcome assessment; binding affinity; protein domain; antigen expression; lymphocyte proliferation; t-lymphocytes; animals; tumor volume; bendamustine; cyclophosphamide; antineoplastic activity; chimera; minimal residual disease; tumor burden; recombinant proteins; adoptive cell therapy; chimeric antigen receptor; adoptive transfer; gamma irradiation; electroporation; cytokine production; immunophenotyping; drug cytotoxicity; cancer control; cytokine release; leukemia relapse; chronic lymphatic leukemia; immunotherapy, adoptive; t lymphocyte activation; lymphocytopoiesis; cd19 antigen; lymphocyte antigen receptor; antigens, cd19; leukemia, lymphocytic, chronic, b-cell; receptors, antigen; lymphocyte count; pentostatin; leukemia remission; cancer gene therapy; chronic lymphocytic leukemia; cd19; cancer prognosis; cell engineering |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 27 |
| Issue: | 2 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-04-01 |
| Start Page: | 341 |
| End Page: | 353 |
| Language: | English |
| PROVIDER: | scopus |
| PMCID: | PMC3615434 |
| PUBMED: | 23561477 |
| DOI: | 10.1016/j.hoc.2012.12.004 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: HCNAE" - ":doi 10.1016/j.hoc.2012.12.004" - "Source: Scopus" |
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