Desmoplastic melanoma: A review Journal Article
| Authors: | Chen, L. L.; Jaimes, N.; Barker, C. A.; Busam, K. J.; Marghoob, A. A. |
| Article Title: | Desmoplastic melanoma: A review |
| Abstract: | Desmoplastic melanoma (DM) is a variant of spindle cell melanoma typically found on chronically sun-damaged skin of older individuals. Early diagnosis can be challenging because it is often amelanotic and has a predominantly dermal component. DM can be difficult to diagnose not only clinically but also histologically, and can be mistaken for a variety of benign and malignant nonmelanocytic spindle cell tumors when viewed on prepared histopathology slides. Pathologists have observed that DMs can manifest significant variation with respect to the extent of intratumoral cellularity, fibrosis, and/or perineural invasion. Furthermore, some tumors present with a pure desmoplastic invasive component (>90%) while other tumors display mixed features of DM and nondesmoplastic melanoma. This has led to the separation of DM into 2 histologic subtypes, pure and mixed. With a focus on the distinction between pure and mixed DM, this review will detail what is currently known about the diagnostic features of DM, discuss risk and prognostic factors, and examine the current literature on disease progression and management. © 2012 by the American Academy of Dermatology, Inc. |
| Keywords: | sentinel lymph node biopsy; melanoma; dermoscopy; risk factors; pathology; desmoplastic melanoma |
| Journal Title: | Journal of the American Academy of Dermatology |
| Volume: | 68 |
| Issue: | 5 |
| ISSN: | 0190-9622 |
| Publisher: | Mosby Elsevier |
| Date Published: | 2013-05-01 |
| Start Page: | 825 |
| End Page: | 833 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 23267722 |
| DOI: | 10.1016/j.jaad.2012.10.041 |
| PMCID: | PMC4703041 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 May 2013" - "CODEN: JAADD" - ":doi 10.1016/j.jaad.2012.10.041" - "Source: Scopus" |
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534Marghoob -
218Barker -
21Jaimes Lopez -
688Busam -
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