Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: A gynecologic oncology group study Journal Article
| Authors: | Farley, J. H.; Tian, C.; Rose, G. S.; Brown, C. L.; Birrer, M.; Risinger, J. I.; Thigpen, J. T.; Fleming, G. F.; Gallion, H. H.; Maxwell, G. L. |
| Article Title: | Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancer: A gynecologic oncology group study |
| Abstract: | BACKGROUND: The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival. METHODS: A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles ≥7 were defined as treatment completion. RESULTS: Although black patients were more likely to experience grades 3-4 anemia (20% vs 14%) and genitourinary (5% vs 1%) toxicity, and less likely to experience severe gastrointestinal toxicity (10% vs 17%), the overall incidence of grades 3-4 treatment-related chemotoxicity was the same between the 2 groups (82% vs 82%). There were no differences in the number of cycles received, relative dose (0.57 vs 0.58), relative time (0.77 vs 0.78), or relative dose intensity (0.76 vs 0.76) for black and white patients. CONCLUSIONS: Black patients with advanced stage or recurrent endometrial cancer, treated on 4 Gynecologic Oncology Group (GOG) protocols, had similar dose intensity and severe chemotherapy-related toxicity compared with white patients, suggesting that previously described racial disparities in survival among patients in GOG trials may have an novel etiology. © 2010 American Cancer Society. |
| Keywords: | cancer survival; controlled study; treatment outcome; treatment response; major clinical study; neutropenia; cisplatin; doxorubicin; advanced cancer; cancer combination chemotherapy; dose response; drug dose reduction; drug withdrawal; treatment duration; paclitaxel; cancer adjuvant therapy; chemotherapy, adjuvant; chemotherapy; cancer staging; neurotoxicity; recurrent cancer; endometrial cancer; endometrial neoplasms; endometrium cancer; multiple cycle treatment; anemia; leukopenia; thrombocytopenia; antineoplastic combined chemotherapy protocols; drug administration schedule; randomized controlled trials as topic; recurrence; medical record review; gastrointestinal toxicity; cardiovascular disease; age distribution; urogenital tract disease; race difference; african americans; european continental ancestry group; granulocyte colony stimulating factor; caucasian; negro; gog |
| Journal Title: | Cancer |
| Volume: | 116 |
| Issue: | 2 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2010-01-15 |
| Start Page: | 355 |
| End Page: | 361 |
| Language: | English |
| DOI: | 10.1002/cncr.24769 |
| PUBMED: | 19924790 |
| PROVIDER: | scopus |
| PMCID: | PMC2811766 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CANCA" - "Source: Scopus" |
