Localized intrapancreatic malignant mesothelioma: A rare entity that may be confused with other pancreatic neoplasms Journal Article
| Authors: | Espinal-Witter, R.; Servais, E. L.; Klimstra, D. S.; Lieberman, M. D.; Yantiss, R. K. |
| Article Title: | Localized intrapancreatic malignant mesothelioma: A rare entity that may be confused with other pancreatic neoplasms |
| Abstract: | Malignant mesothelioma usually presents with diffuse involvement of the pleura or peritoneum. Circumscribed or localized malignant mesothelioma has been described in these locations, as well as the viscera, in which case it may cause diagnostic confusion with other, more common entities. Herein, we describe the first well-documented case of primary intrapancreatic malignant mesothelioma in the English literature. The patient was an otherwise healthy 39-year-old woman who presented with a symptomatic mass in the head of the pancreas that was completely resected via pancreaticoduodenectomy. The tumor was composed of cysts, papillae, and tubules lined by cells with abundant eosinophilic cytoplasm and immunohistochemically expressed CA-125, calretinin, and D2-40. Follow-up revealed no evidence of residual or recurrent disease 32 months after surgery. This report also describes the clinical and pathologic characteristics of an intrapancreatic mesothelioma and provides a review of the literature regarding entities that may be considered in the differential diagnosis of this tumor. © 2010 Springer-Verlag. |
| Keywords: | immunohistochemistry; adult; protein expression; cancer surgery; histopathology; cancer localization; cancer recurrence; case report; pancreas cancer; pancreatic neoplasms; follow up; pancreaticoduodenectomy; diagnosis, differential; differential diagnosis; minimal residual disease; pancreas tumor; malignant mesothelioma; ca 125 antigen; calretinin; monoclonal antibody d2-40; epithelioid; pancreatic tumor; solitary fibrous tumor, pleural |
| Journal Title: | Virchows Archiv |
| Volume: | 456 |
| Issue: | 4 |
| ISSN: | 0945-6317 |
| Publisher: | Springer |
| Date Published: | 2010-04-01 |
| Start Page: | 455 |
| End Page: | 461 |
| Language: | English |
| DOI: | 10.1007/s00428-010-0885-9 |
| PUBMED: | 20148337 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: VARCE" - "Source: Scopus" |
