Dose dense cyclophosphamide, methotrexate, fluorouracil is feasible at 14-day intervals: a pilot study of every-14-day dosing as adjuvant therapy for breast cancer Journal Article

   

Authors:	Drullinsky, P.; Sugarman, S. M.; Fornier, M. N.; D'Andrea, G.; Gilewski, T.; Lake, D.; Traina, T.; Wasserheit-Lieblich, C.; Sklarin, N.; Atieh-Graham, D.; Mills, N.; Troso-Sandoval, T.; Seidman, A. D.; Yuan, J.; Patel, H.; Patil, S.; Norton, L.; Hudis, C.
Article Title:	Dose dense cyclophosphamide, methotrexate, fluorouracil is feasible at 14-day intervals: a pilot study of every-14-day dosing as adjuvant therapy for breast cancer
Abstract:	Cyclophosphamide/methotrexate/fluorouracil (CMF) is a proven adjuvant option for patients with early-stage breast cancer. Randomized trials with other regimens demonstrate that dose-dense (DD) scheduling can offer greater efficacy. We investigated the feasibility of administering CMF using a DD schedule. Thirty-eight patients with early-stage breast cancer were accrued from March 2008 through June 2008. They were treated every 14 days with C 600, M 40, F 600 (all mg/m2) with PEG-filgrastim (Neulasta®) support on day 2 of each cycle. The primary endpoint was tolerability using a Simon's 2-stage optimal design. The design would effectively discriminate between true tolerability (as protocol-defined) rates of ≤ 60% and ≥ 80%. The median age was 52-years-old (range, 38-78 years of age). Twenty-nine of the 38 patients completed 8 cycles of CMF at 14-day intervals. Dose-dense adjuvant CMF is tolerable and feasible at 14-day intervals with PEG-filgrastim support.
Keywords:	adult; treatment outcome; aged; middle aged; clinical trial; fluorouracil; dose response; antineoplastic agents; chemotherapy, adjuvant; methotrexate; cancer staging; antineoplastic agent; neoplasm staging; adenocarcinoma; antineoplastic combined chemotherapy protocols; drug administration schedule; cyclophosphamide; pathology; dose-response relationship, drug; breast neoplasms; feasibility study; pilot study; feasibility studies; pilot projects; adjuvant chemotherapy; breast tumor; drug administration
Journal Title:	Clinical Breast Cancer
Volume:	10
Issue:	6
ISSN:	1526-8209
Publisher:	Elsevier Inc.
Date Published:	2010-12-01
Start Page:	440
End Page:	444
Language:	English
PUBMED:	21147686
PROVIDER:	scopus
DOI:	10.3816/CBC.2010.n.057
PMCID:	PMC3661192
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79952296321&partnerID=40&md5=7d497205d979e9146abf5e81dd8bb677
Notes:	--- - "Export Date: 20 April 2011" - "Source: Scopus"

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