On the potential of natural products in the discovery of pharma leads: A case for reassessment Journal Article
| Author: | Danishefsky, S. |
| Article Title: | On the potential of natural products in the discovery of pharma leads: A case for reassessment |
| Abstract: | The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation. © 2010 The Royal Society of Chemistry. |
| Keywords: | review; mouse; animal; animals; mice; drug discovery; drug development; chemistry; chemical structure; molecular structure; macrolide; synthesis; biological product; biological products; epothilones; epothilone derivative; migrastatin; piperidone derivative; myxococcales; streptomyces; macrolides; piperidones |
| Journal Title: | Natural Product Reports |
| Volume: | 27 |
| Issue: | 8 |
| ISSN: | 0265-0568 |
| Publisher: | Royal Society of Chemistry |
| Date Published: | 2010-08-01 |
| Start Page: | 1114 |
| End Page: | 1116 |
| Language: | English |
| DOI: | 10.1039/c003211p |
| PUBMED: | 20383353 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 10" - "Export Date: 20 April 2011" - "CODEN: NPRRD" - "Source: Scopus" |
