Locoregional outcomes of inflammatory breast cancer patients treated with standard fractionation radiation and daily skin bolus in the taxane era Journal Article
| Authors: | Damast, S.; Ho, A. Y.; Montgomery, L.; Fornier, M. N.; Ishill, N.; Elkin, E.; Beal, K.; McCormick, B. |
| Article Title: | Locoregional outcomes of inflammatory breast cancer patients treated with standard fractionation radiation and daily skin bolus in the taxane era |
| Abstract: | Purpose: To assess locoregional outcomes of inflammatory breast cancer (IBC) patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy (CMT). Methods and Materials: We retrospectively reviewed the charts of 107 patients diagnosed with IBC between January 1995 and March 2006 who presented to our department for adjuvant radiation therapy (RT). Results: All patients received chemotherapy (95% anthracycline and 95% taxane), modified radical mastectomy, and RT to the chest wall and regional lymphatics using standard fractionation to 50 Gy and daily skin bolus. The RT to the chest wall was delivered via electrons (55%) or photons (45%) in daily fractions of 180 cGy (73%) or 200 cGy (27%). Scar boost was performed in 11%. A majority (84%) of patients completed the prescribed treatment. Median follow-up was 47 months (range, 10-134 months). Locoregional control (LRC) at 3 years and 5 years was 90% and 87%, respectively. Distant metastases-free survival (DMFS) at 3 years and 5 years was 61% and 47%, respectively. Conclusions: Excellent locoregional control was observed in this population of IBC patients who received standard fractionation radiation with daily skin bolus and taxanes as part of combined-modality therapy. Distant metastases-free survival remains a significant therapeutic challenge. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | adult; aged; aged, 80 and over; disease-free survival; middle aged; retrospective studies; major clinical study; doxorubicin; fluorouracil; multimodality cancer therapy; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; disease free survival; neoadjuvant therapy; radiotherapy, adjuvant; chemotherapy; methotrexate; outcome assessment; follow up; adenocarcinoma; carboplatin; breast cancer; radiation; mastectomy; antineoplastic combined chemotherapy protocols; drug administration schedule; radiotherapy; aromatase inhibitor; cyclophosphamide; patient monitoring; pathology; breast neoplasms; medical record review; distant metastasis; docetaxel; lymph vessel; prescription; radiation dose fractionation; tamoxifen; epirubicin; taxane derivative; cancer control; dose fractionation; anthracycline; deoxycytidine; locoregional control; photon; thorax wall; taxanes; standards; electron; radiodermatitis; combined modality treatment; inflammatory breast cancer; standard fractionation; adjuvant radiation; chest wall; radiation standards; radical mastectomy; mastectomy, modified radical |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 77 |
| Issue: | 4 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-07-15 |
| Start Page: | 1105 |
| End Page: | 1112 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2009.06.042 |
| PUBMED: | 19879068 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IOBPD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work