Evolutionary conservation of meiotic DSB proteins: More than just Spo11 Journal Article

   


Authors: Cole, F.; Keeney, S.; Jasin, M.
Article Title: Evolutionary conservation of meiotic DSB proteins: More than just Spo11
Abstract: Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse. © 2010 by Cold Spring Harbor Laboratory Press.
Keywords: review; nonhuman; protein function; protein motif; protein analysis; oocyte; cytology; meiosis; animals; mice; dna repair; protein protein interaction; evolution, molecular; double stranded dna; genetic recombination; molecular evolution; conserved sequence; dna breaks, double-stranded; double stranded dna break; saccharomycetales; saccharomyces cerevisiae protein; genetic screening; zinc finger protein; ubiquitin-protein ligases; histone h2ax; genetic conservation; chromosomes; rad51 protein; dna cleavage; chromosomal localization; spo11 protein; dna topoisomerase; esterases; meiotic prophase i; zinc finger motif; recombination; crossing over, genetic; arabidopsis; double-strand break; caenorhabditis elegans protein; crossover junction endodeoxyribonuclease; vegetable protein; evolutionary homology; gene synthesis; orthology; yeast artificial chromosome; recombinases
Journal Title: Genes and Development
Volume: 24
Issue: 12
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2010-06-15
Start Page: 1201
End Page: 1207
Language: English
DOI: 10.1101/gad.1944710
PUBMED: 20551169
PROVIDER: scopus
PMCID: PMC2885656
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77953925453&partnerID=40&md5=f3f95546c78d58d4ab5858a6fec7ba8a
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "CODEN: GEDEE" - "Source: Scopus"
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MSK Authors
  1. Scott N Keeney
    138 Keeney
  2. Maria Jasin
    249 Jasin
  3. Francesca Cole
    10 Cole
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