High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer Journal Article

   

Authors:	Clarke, J. L.; Pao, W.; Wu, N.; Miller, V.; Lassman, A. B.
Article Title:	High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer
Abstract:	Leptomeningeal metastases (LM) occur in 5-10% of patients with solid tumors and are associated with a dismal prognosis. We describe LM from lung adenocarcinoma harboring a mutation in the epidermal growth factor receptor (EGFR) gene that confers sensitivity to the EGFR tyrosine kinase inhibitors (EGFR-TKIs) erlotinib and gefitinib. The CSF concentration of EGFR-TKIs achieved by standard daily dosing may be insufficient for therapeutic effect. However, intermittent (pulsatile) high dose administration (1000-1500 mg/week) achieves a higher CSF concentration than standard dosing, and successfully controlled LM in this patient. © 2010 Springer Science+Business Media, LLC.
Keywords:	adult; treatment outcome; middle aged; gene mutation; mutation; case report; erlotinib; drug dose comparison; paclitaxel; temozolomide; drug megadose; adenocarcinoma; carboplatin; lung non small cell cancer; lung neoplasms; epidermal growth factor receptor; lung cancer; receptor, epidermal growth factor; cetuximab; protein kinase inhibitors; lung adenocarcinoma; meningeal neoplasms; gefitinib; brain metastasis; egfr; quinazolines; drug sensitivity; pemetrexed; leptomeningeal metastases; drug cerebrospinal fluid level; leptomeningeal metastasis
Journal Title:	Journal of Neuro-Oncology
Volume:	99
Issue:	2
ISSN:	0167-594X
Publisher:	Springer
Date Published:	2010-09-01
Start Page:	283
End Page:	286
Language:	English
DOI:	10.1007/s11060-010-0128-6
PUBMED:	20146086
PROVIDER:	scopus
PMCID:	PMC3973736
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77956060394&partnerID=40&md5=2aca7cef239aef24acc7d04663245d9d
Notes:	--- - "Cited By (since 1996): 4" - "Export Date: 20 April 2011" - "CODEN: JNODD" - "Source: Scopus"

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