Aire-dependent thymic development of tumor-associated regulatory T cells Journal Article


Authors: Malchow, S.; Leventhal, D. S.; Nishi, S.; Fischer, B. I.; Shen, L.; Paner, G. P.; Amit, A. S.; Kang, C.; Geddes, J. E.; Allison, J. P.; Socci, N. D.; Savage, P. A.
Article Title: Aire-dependent thymic development of tumor-associated regulatory T cells
Abstract: Despite considerable interest in the modulation of tumor-associated Foxp3+ regulatory T cells (Tregs) for therapeutic benefit, little is known about the developmental origins of these cells and the nature of the antigens that they recognize. We identified an endogenous population of antigen-specific Tregs (termed MJ23 Tregs) found recurrently enriched in the tumors of mice with oncogene-driven prostate cancer. MJ23 Tregs were not reactive to a tumor-specific antigen but instead recognized a prostate-associated antigen that was present in tumor-free mice. MJ23 Tregs underwent autoimmune regulator (Aire)-dependent thymic development in both male and female mice. Thus, Aire-mediated expression of peripheral tissue antigens drives the thymic development of a subset of organ-specific Tregs, which are likely coopted by tumors developing within the associated organ.
Journal Title: Science
Volume: 339
Issue: 6124
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2013-03-08
Start Page: 1219
End Page: 1224
Language: English
DOI: 10.1126/science.1233913
PROVIDER: scopus
PUBMED: 23471412
PMCID: PMC3622085
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 1 April 2013" - "CODEN: SCIEA" - "Source: Scopus"
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  1. Peter A Savage
    3 Savage
  2. James P Allison
    130 Allison
  3. Jenna Geddes
    1 Geddes
  4. Nicholas D Socci
    266 Socci