Modular 'click-in-emulsion' bone-targeted nanogels Journal Article
| Authors: | Heller, D. A.; Levi, Y.; Pelet, J. M.; Doloff, J. C.; Wallas, J.; Pratt, G. W.; Jiang, S.; Sahay, G.; Schroeder, A.; Schroeder, J. E.; Chyan, Y.; Zurenko, C.; Querbes, W.; Manzano, M.; Kohane, D. S.; Langer, R.; Anderson, D. G. |
| Article Title: | Modular 'click-in-emulsion' bone-targeted nanogels |
| Abstract: | A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keywords: | nanotechnology; drug delivery; polymers; bones; nanogels |
| Journal Title: | Advanced Materials |
| Volume: | 25 |
| Issue: | 10 |
| ISSN: | 0935-9648 |
| Publisher: | Wiley V C H Verlag Gmbh |
| Date Published: | 2013-03-13 |
| Start Page: | 1449 |
| End Page: | 1454 |
| Language: | English |
| DOI: | 10.1002/adma.201202881 |
| PROVIDER: | scopus |
| PUBMED: | 23280931 |
| PMCID: | PMC3815631 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 April 2013" - "CODEN: ADVME" - "Source: Scopus" |
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