Coordinate transcriptional regulation by ERG and androgen receptor in fusion-positive prostate cancers Journal Article
| Authors: | Chen, Y.; Sawyers, C. L. |
| Article Title: | Coordinate transcriptional regulation by ERG and androgen receptor in fusion-positive prostate cancers |
| Abstract: | In this issue of Cancer Cell, Yu and colleagues mapped the genomic binding sites of ERG and androgen receptor, two crucial transcription factors in prostate cancer. There is an extraordinary degree of overlap between binding sites, with the suggestion that ERG inhibits androgen receptor-mediated differentiation and promotes EZH2-mediated dedifferentiation. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; cancer growth; nonhuman; protein function; protein motif; prostate specific antigen; protein analysis; protein protein interaction; tumor differentiation; carcinogenesis; prostate cancer; cancer genetics; transcription regulation; transcription factor erg; short survey; binding site; androgen receptor; transcription factor ezh2; cell dedifferentiation; citrus maxima |
| Journal Title: | Cancer Cell |
| Volume: | 17 |
| Issue: | 5 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2010-05-18 |
| Start Page: | 415 |
| End Page: | 416 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2010.04.022 |
| PROVIDER: | scopus |
| PMCID: | PMC2931314 |
| PUBMED: | 20478521 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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