Elevated serum levels of TPS and CYFRA 21-1 predict poor prognosis in advanced non-small-cell lung cancer patients treated with gefitinib Journal Article


Authors: Chen, F.; Luo, X.; Zhang, J.; Lu, Y.; Luo, R.
Article Title: Elevated serum levels of TPS and CYFRA 21-1 predict poor prognosis in advanced non-small-cell lung cancer patients treated with gefitinib
Abstract: Serum concentrations of tissue polypeptide-specific antigen (TPS) and Cytokeratin-19-Fragments (CYFRA 21-1) before operation or chemotherapy have been proved to be a useful prognostic tool for patients with NSCLC, but the related data for advanced NSCLC patients treated with gefitinib are limited. We retrospectively reviewed 122 advanced NSCLC patients treated with gefitinib between April 2002 and August 2007. Multiple clinical factors including pretreatment serum levels of TPS and CYFRA 21-1, age, gender, performance status (PS), smoking history, stage, histology, the number of prior chemotherapy and the patients' clinical outcomes were analyzed. Patients without elevated serum TPS levels had a more RR (36.8%) than those with elevated serum TPS levels (18.5%) (P = 0.023), nevertheless, a similar result was not seen in patients with normal CYFRA 21-1 levels. For patients with normal vs. high TPS levels, the median survival times (MSTs) were 15.9 vs. 7.3 months (P = 0.001). For patients with normal vs. high CYFRA 21-1, the MSTs were 15.4 vs. 7.5 months (P = 0.003). Moreover, for patients with both elevated, vs. one elevated and both normal TPS and CYFRA 21-1 levels, the MSTs were 5.4 vs. 11.4 months (P = 0.001), and 16.5 months (P < 0.001), respectively. In multivariate analysis, TPS (P = 0.001) and CYFRA 21-1 (P = 0.005) alone or combination (P < 0.001) remained significant correlation to survival. In NSCLC patients with gefitinib therapy, pretreatment serum levels of TPS and CYFRA 21-1 alone or combined might be independent prognostic factors, and the pretreatment serum TPS level may predict the tumor response. © 2009 Humana Press Inc.
Keywords: adult; cancer chemotherapy; treatment response; aged; middle aged; retrospective studies; unclassified drug; major clinical study; advanced cancer; antineoplastic agents; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; proportional hazards models; neoplasm proteins; tumor markers, biological; smoking; risk assessment; protein kinase inhibitors; survival time; correlation analysis; antigen; antigens, neoplasm; gefitinib; peptides; quinazolines; non-small-cell lung cancer; prognostic factor; cytokeratin-19-fragments; tissue polypeptide-specific antigen; cytokeratin 19 fragment; tissue polypeptide specific antigen; kaplan-meier estimate; keratin-19
Journal Title: Medical Oncology
Volume: 27
Issue: 3
ISSN: 1357-0560
Publisher: Humana Press Inc  
Date Published: 2010-09-01
Start Page: 950
End Page: 957
Language: English
DOI: 10.1007/s12032-009-9315-8
PUBMED: 19830603
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: MONCE" - "Source: Scopus"
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  1. Yang Lu
    11 Lu