The perivascular niche microenvironment in brain tumor progression Journal Article
| Authors: | Charles, N.; Holland, E. C. |
| Article Title: | The perivascular niche microenvironment in brain tumor progression |
| Abstract: | Glioblastoma, the most frequent and aggressive malignant brain tumor, has a very poor prognosis of approximately 1-year. The associated aggressive phenotype and therapeutic resistance of glioblastoma is postulated to be due to putative brain tumor stem-like cells (BTSC). The best hope for improved therapy lies in the ability to understand the molecular biology that controls BTSC behavior. The tumor vascular microenvironment of brain tumors has emerged as important regulators of BTSC behavior. Emerging data have identified the vascular microenvironment as home to a multitude of cell types engaged in various signaling that work collectively to foster a supportive environment for BTSCs. Characterization of the signaling pathways and intercellular communication between resident cell types in the microvascular niche of brain tumors is critical to the identification of potential BTSC-specific targets for therapy. © 2010 Landes Bioscience. |
| Keywords: | signal transduction; protein kinase b; review; nonhuman; brain tumor; brain neoplasms; phenotype; animals; cell function; astrocyte; notch receptor; cell population; vascularization; phosphatidylinositol 3 kinase; cell type; endothelium cell; neoplastic stem cells; disease progression; glioblastoma; cancer stem cell; fibroblast; microenvironment; tumor growth; cell communication; wnt protein; stem cell niche; immunocompetent cell; extracellular space; perivascular niche; tumor microenvironment; nitric oxide; molecularly targeted therapy; cancer stem-like cells; cyclic gmp; pericyte |
| Journal Title: | Cell Cycle |
| Volume: | 9 |
| Issue: | 15 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2010-08-01 |
| Start Page: | 3012 |
| End Page: | 3021 |
| Language: | English |
| DOI: | 10.4161/cc.9.15.12710 |
| PUBMED: | 20714216 |
| PROVIDER: | scopus |
| PMCID: | PMC3040926 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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