A prospective study of quality of life in patients undergoing pelvic exenteration: Interim results Journal Article
| Authors: | Rezk, Y. A.; Hurley, K. E.; Carter, J.; Dao, F.; Bochner, B. H.; Aubey, J. J.; Caceres, A.; Einstein, M. H.; Abu-Rustum, N. R.; Barakat, R. R.; Makker, V.; Chi, D. S. |
| Article Title: | A prospective study of quality of life in patients undergoing pelvic exenteration: Interim results |
| Abstract: | Objective: Little prospective data exist on quality of life (QOL) after pelvic exenteration (PE). This ongoing study prospectively examines the QOL changes following this radical procedure using a comprehensive battery of psychological instruments. Methods: Since 2005, enrolled patients were interviewed (EORTC QLQ-C30, EORTC QLQ-CR38, EORTC QLQ-BLM30, BFI, BPI-SF, IADL, CES-D, IES-R) preoperatively and at 3, 6, and 12 months after PE for physical/psychological symptoms. Data were examined using repeated measure ANOVA. Results: Sixteen women (3 anterior, 1 posterior, and 12 total PEs), with more than 1 year of follow-up, completed all scheduled interviews. Median age was 58 years (range, 28-76 years). Overall QOL (F = 6.3, p < 0.02), ability to perform instrumental daily activities (F = 6.8, p < 0.02), body image (F = 11.9, p < 0.00), and sexual function (F = 8.0, p < 0.01) all declined at 3 months but were near baseline by 12 months after PE. Although, overall, physical function followed a similar trend (F = 14.8, p < 0.00), it did not return to baseline. At the 12-month interview, patients reported increased gastrointestinal symptoms (F = 8.9, p < 0.01) but significantly less stress-related ideation (F = 6.1, p < 0.03) compared to baseline. Pain levels did not change significantly during the study period (F = 0.4, p < 0.74). Conclusions: Although patients report lingering gastrointestinal symptoms and some persistent decline in physical function after PE, most adjust well, returning to almost baseline functioning within a year. Providers can counsel patients that many, though not all, symptoms in the first 3 months following exenteration are likely to improve as they adapt to their changed health status. These preliminary results await confirmation of a larger analysis. © 2012 Elsevier Inc. All rights reserved. |
| Keywords: | adult; clinical article; aged; preoperative care; follow up; prospective study; quality of life; pain; gastrointestinal symptom; psychological aspect; daily life activity; observational study; psychological well being; sexual function; patient counseling; longitudinal study; pelvic exenteration; pelvic examination; quality of life index |
| Journal Title: | Gynecologic Oncology |
| Volume: | 128 |
| Issue: | 2 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2013-02-01 |
| Start Page: | 191 |
| End Page: | 197 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2012.09.030 |
| PROVIDER: | scopus |
| PUBMED: | 23063761 |
| PMCID: | PMC4174356 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "CODEN: GYNOA" - "Source: Scopus" |
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