Microenvironment-mediated resistance to anticancer therapies Journal Article
| Authors: | Olson, O. C.; Joyce, J. A. |
| Article Title: | Microenvironment-mediated resistance to anticancer therapies |
| Abstract: | Resistance to molecularly targeted therapies can result from genomic alterations in the tumor cells that reactivate oncogenic signaling. Less is known of tumor cell-extrinsic mechanisms of resistance to targeted therapies. Two recent studies have identified HGF as a soluble factor capable of mediating resistance to BRAF and HER2 inhibitors in a paracrine manner. These new findings suggest an important role for the tumor microenvironment in mediating resistance to molecularly targeted therapies. © 2013 IBCB, SIBS, CAS All rights reserved. |
| Journal Title: | Cell Research |
| Volume: | 23 |
| Issue: | 2 |
| ISSN: | 1001-0602 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-02-01 |
| Start Page: | 179 |
| End Page: | 181 |
| Language: | English |
| DOI: | 10.1038/cr.2012.123 |
| PROVIDER: | scopus |
| PMCID: | PMC3567818 |
| PUBMED: | 22945358 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "Source: Scopus" |
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