Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors Journal Article
| Authors: | Chmielecki, J.; Crago, A. M.; Rosenberg, M.; O'Connor, R.; Walker, S. R.; Ambrogio, L.; Auclair, D.; McKenna, A.; Heinrich, M. C.; Frank, D. A.; Meyerson, M. |
| Article Title: | Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors |
| Abstract: | Solitary fibrous tumors (SFTs) are rare mesenchymal tumors. Here, we describe the identification of a NAB2-STAT6 fusion from whole-exome sequencing of 17 SFTs. Analysis in 53 tumors confirmed the presence of 7 variants of this fusion transcript in 29 tumors (55%), representing a lower bound for fusion frequency at this locus and suggesting that the NAB2-STAT6 fusion is a distinct molecular feature of SFTs. © 2013 Nature America, Inc. All rights reserved. |
| Keywords: | unclassified drug; reverse transcription polymerase chain reaction; gene locus; transcription factor; tumor recurrence; fibroma; dna sequence; repressor protein; soft tissue tumor; dna transcription; exome; stat6 protein; transcription factor nab2 |
| Journal Title: | Nature Genetics |
| Volume: | 45 |
| Issue: | 2 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2013-02-01 |
| Start Page: | 131 |
| End Page: | 132 |
| Language: | English |
| DOI: | 10.1038/ng.2522 |
| PROVIDER: | scopus |
| PUBMED: | 23313954 |
| PMCID: | PMC3984043 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "CODEN: NGENE" - "Source: Scopus" |
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