Prognostic implications of additional chromosome abnormalities among patients with de novo acute promyelocytic leukemia with t(15;17) Journal Article
| Authors: | Wiernik, P. H.; Sun, Z.; Gundacker, H.; Dewald, G.; Slovak, M. L.; Paietta, E.; Kim, H. T.; Appelbaum, F. R.; Cassileth, P. A.; Tallman, M. S. |
| Article Title: | Prognostic implications of additional chromosome abnormalities among patients with de novo acute promyelocytic leukemia with t(15;17) |
| Abstract: | This retrospective study performed by the Eastern Cooperative Oncology Group and the Southwest Oncology Group enrolled 140 acute promyelocytic leukemia (APL) patients with t(15;17) to determine the influence of additional karyotypic abnormalities on treatment outcome. Karyotypes were centrally reviewed by both study groups. The complete response rate after induction for patients with t(15;17) treated with chemotherapy, or alltrans retinoic acid (ATRA) as induction therapy was not affected by additional cytogenetic aberrations. Disease-free (DFS) and overall survival (OS) were unaffected by additional cytogenetic abnormalities if treatment was chemotherapy without ATRA. Patients with t(15;17) only, treated with ATRA with or without chemotherapy, had an improved DFS (P = 0.06) and a better OS (P = 0.01) compared with ATRA-treated patients with additional cytogenetic abnormalities. Patients with APL and t(15;17) alone are significantly more sensitive to treatment with ATRA than are patients with t(15;17) and additional cytogenetic abnormalities. Copyright © Springer Science+Business Media, LLC 2012. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; treatment outcome; treatment response; aged; major clinical study; overall survival; disease free survival; retrospective study; chromosome aberration; promyelocytic leukemia; karyotype; retinoic acid; acute promyelocytic leukemia; all-trans retinoic acid; cancer prognosis; t(15; 17); de novo acute promyelocytic leukemia |
| Journal Title: | Medical Oncology |
| Volume: | 29 |
| Issue: | 3 |
| ISSN: | 1357-0560 |
| Publisher: | Humana Press Inc |
| Date Published: | 2012-09-01 |
| Start Page: | 2095 |
| End Page: | 2101 |
| Language: | English |
| DOI: | 10.1007/s12032-012-0251-7 |
| PROVIDER: | scopus |
| PMCID: | PMC3568758 |
| PUBMED: | 22729365 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "CODEN: MONCE" - "Source: Scopus" |
