New pieces of a puzzle: The current biological picture of MPN Journal Article
| Authors: | Kleppe, M.; Levine, R. L. |
| Article Title: | New pieces of a puzzle: The current biological picture of MPN |
| Abstract: | Over the last years, we have witnessed significant improvement in our ability to elucidate the genetic events, which contribute to the pathogenesis of acute and chronic leukemias, and also in patients with myeloproliferative neoplasms (MPN). However, despite significant insight into the role of specific mutations, including the JAK2V617F mutation, in MPN pathogenesis, the precise mechanisms by which specific disease alleles contribute to leukemic transformation in MPN remain elusive. Here we review recent studies aimed at understanding the role of downstream signaling pathways in MPN initiation and phenotype, and discuss how these studies have begun to lead to novel insights with biologic, clinical, and therapeutic relevance. © 2012 Elsevier B.V. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein kinase b; myeloproliferative disorders; leukemia; mutation; janus kinase 2; review; raf protein; nonhuman; drug targeting; protein function; phenotype; animals; anemia; signaling; inhibitor of differentiation 1; thrombocytopenia; genetic association; mutational analysis; phosphatidylinositol 3 kinase; mutator gene; epigenetics; cyclin dependent kinase inhibitor 1b; leukemogenesis; mammalian target of rapamycin; proto-oncogene proteins c-akt; extracellular signal-regulated map kinases; ras protein; bcr abl protein; protein tyrosine phosphatase; mitogen activated protein kinase kinase; myeloproliferative neoplasm; stat protein; cyclin d2; stat3; molecularly targeted therapy; janus kinase 2 inhibitor; phosphatidylinositol 3-kinases; jak2; tor serine-threonine kinases; jak2 gene; protein kinase pim 1; mpn |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Volume: | 1826 |
| Issue: | 2 |
| ISSN: | 0304-419X |
| Publisher: | Elsevier B.V. |
| Date Published: | 2012-12-01 |
| Start Page: | 415 |
| End Page: | 422 |
| Language: | English |
| DOI: | 10.1016/j.bbcan.2012.07.002 |
| PUBMED: | 22824378 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 14 February 2013" - "CODEN: BBACE" - "Source: Scopus" |
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