Lungs don't forget: Comparison of the KRAS and EGFR mutation profile and survival of collegiate smokers and never smokers with advanced lung cancers Journal Article


Authors: Varghese, A. M.; Sima, C. S.; Chaft, J. E.; Johnson, M. L.; Riely, G. J.; Ladanyi, M.; Kris, M. G.
Article Title: Lungs don't forget: Comparison of the KRAS and EGFR mutation profile and survival of collegiate smokers and never smokers with advanced lung cancers
Abstract: BACKGROUND: We hypothesize that among patients with lung cancers the KRAS/EGFR mutation profile and overall survival of collegiate smokers (former smokers who smoked between 101 lifetime cigarettes and 5 pack-years) are distinct from those of never smokers and former smokers with 15 pack-years or more. METHODS: We collected age, sex, stage, survival, and smoking history for patients evaluated from 2004 to 2009 with advanced stage lung cancers and known KRAS/EGFR status. Mutation profile and overall survival were compared using Fisher's exact test and log-rank test, respectively. RESULTS: Data were available for 852 patients with advanced-stage lung cancers with known KRAS/EGFR status, of which 6% were collegiate smokers, 36% were never smokers, and 30% were former smokers with 15 pack-years or more. The mutation profile of collegiate smokers (15% KRAS mutations, 27% EGFR mutations) was distinct from those of never smokers (p < 0.001) and former smokers with 15 pack-years or more (p < 0.001) and not significantly different from those of former smokers with 5 to 15 pack-years (p = 0.9). Median overall survival for collegiate smokers was 25 months, compared with 32 months for never smokers (p = 0.4), 33 months for former smokers with 5 to 15 pack-years (p = 0.48), and 21 months for former smokers with 15 pack-years or more (p = 0.63). CONCLUSIONS: Collegiate smokers with advanced-stage lung cancers represent a distinct subgroup of patients with a higher frequency of KRAS mutations and lower frequency of EGFR mutations compared with never smokers. These observations reinforce the recommendation for routine mutation testing for all patients with lung cancers and that no degree of tobacco exposure is safe. Copyright © 2012 by the International Association for the Study of Lung Cancer.
Keywords: kras mutation; collegiate smokers; epidermal growth factor receptor mutation; non-small-cell lung cancers
Journal Title: Journal of Thoracic Oncology
Volume: 8
Issue: 1
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2013-01-01
Start Page: 123
End Page: 125
Language: English
DOI: 10.1097/JTO.0b013e31827914ea
PROVIDER: scopus
PMCID: PMC3534987
PUBMED: 23242442
DOI/URL:
Notes: --- - "Export Date: 1 February 2013" - "Source: Scopus"
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MSK Authors
  1. Camelia S Sima
    212 Sima
  2. Melissa Lynne Johnson
    19 Johnson
  3. Marc Ladanyi
    971 Ladanyi
  4. Jamie Erin Chaft
    151 Chaft
  5. Gregory J Riely
    390 Riely
  6. Mark Kris
    687 Kris