Expression of miR-124 inhibits growth of medulloblastoma cells Journal Article
| Authors: | Silber, J.; Hashizume, R.; Felix, T.; Hariono, S.; Yu, M.; Berger, M. S.; Huse, J. T.; Vandenberg, S. R.; David James, C.; Graeme Hodgson, J.; Gupta, N. |
| Article Title: | Expression of miR-124 inhibits growth of medulloblastoma cells |
| Abstract: | Medulloblastoma is the most common malignant brain tumor in children, and a substantial number of patients die as a result of tumor progression. Overexpression of CDK6 is present in approximately one-third of medulloblastomas and is an independent poor prognostic marker for this disease. MicroRNA (miR)-124 inhibits expression of CDK6 and prevents proliferation of glioblastoma and medulloblastoma cells in vitro. We examined the effects of miR-124 overexpression on medulloblastoma cells both in vitro and in vivo and compared cell lines that have low and high CDK6 expression. MiR-124 overexpression inhibits the proliferation of medulloblastoma cells, and this effect is mediated mostly through the action of miR-124 upon CDK6. We further show that induced expression of miR-124 potently inhibits growth of medulloblastoma xenograft tumors in rodents. Further testing of miR-124 will help define the ultimate therapeutic potential of preclinical models of medulloblastoma in conjunction with various delivery strategies for treatment. © 2012 The Author(s). |
| Keywords: | microrna; medulloblastoma; cdk6; d425; mir-124 |
| Journal Title: | Neuro-Oncology |
| Volume: | 15 |
| Issue: | 1 |
| ISSN: | 1522-8517 |
| Publisher: | Oxford University Press |
| Date Published: | 2013-01-01 |
| Start Page: | 83 |
| End Page: | 90 |
| Language: | English |
| DOI: | 10.1093/neuonc/nos281 |
| PROVIDER: | scopus |
| PMCID: | PMC3534424 |
| PUBMED: | 23172372 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2013" - "CODEN: NEURJ" - "Source: Scopus" |
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