Clinical standardized fMRI reveals altered language lateralization in patients with brain tumor Journal Article
| Authors: | Partovi, S.; Jacobi, B.; Rapps, N.; Zipp, L.; Karimi, S.; Rengier, F.; Lyo, J. K.; Stippich, C. |
| Article Title: | Clinical standardized fMRI reveals altered language lateralization in patients with brain tumor |
| Abstract: | BACKGROUND AND PURPOSE: Brain tumors affecting language-relevant areas may influence language lateralization. The purpose of this study was to systematically investigate language lateralization in brain tumor patients using clinical language fMRI, comparing the results with a group of healthy volunteers. MATERIALS AND METHODS: Fifty-seven strictly right-handed patients with left-hemispheric-space intracranial masses (mainly neoplastic) affecting either the Broca area (n = 19) or Wernicke area (n = 38) were prospectively enrolled in this study. Fourteen healthy volunteers served as a control group. Standardized clinical language fMRI, using visually triggered sentence- and word-generation paradigms, was performed on a 1.5T MR scanner. Semiautomated analyses of all functional data were conducted on an individual basis using BrainVoyager. A regional lateralization index was calculated for Broca and Wernicke areas separately versus their corresponding right-hemisphere homologs. RESULTS: In masses affecting the Broca area, a significant decrease in the lateralization index was found when performing word generation (P = .0017), whereas when applying sentence generation, the decrease did not reach statistical significance (P = .851). Masses affecting the Wernicke area induced a significant decrease of the lateralization index when performing sentence generation (P = .0007), whereas when applying word generation, the decrease was not statistically significant (P = .310). CONCLUSIONS: Clinical language fMRI was feasible for patients with brain tumors and provided relevant presurgical information by localizing essential language areas and determining language dominance. A significant effect of the brain masses on language lateralization was observed, with a shift toward the contralesional, nondominant hemisphere. This may reflect compensatory mechanisms of the brain to maintain communicative abilities. |
| Journal Title: | American Journal of Neuroradiology |
| Volume: | 33 |
| Issue: | 11 |
| ISSN: | 0195-6108 |
| Publisher: | American Society of Neuroradiology |
| Date Published: | 2012-12-01 |
| Start Page: | 2151 |
| End Page: | 2157 |
| Language: | English |
| DOI: | 10.3174/ajnr.A3137 |
| PROVIDER: | scopus |
| PUBMED: | 22595902 |
| PMCID: | PMC7965602 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 February 2013" - "CODEN: AAJND" - "Source: Scopus" |
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