Regional liver therapy using oncolytic virus to target hepatic colorectal metastases Journal Article
| Authors: | Carpenter, S. G.; Carson, J.; Fong, Y. |
| Article Title: | Regional liver therapy using oncolytic virus to target hepatic colorectal metastases |
| Abstract: | The mortality of colorectal carcinoma often results from the progression of metastatic disease, which is predominantly hepatic. Although recent advances in surgical, locoregional, and systemic therapies have yielded modest improvements in survival, treatment of these aggressive lesions is limited to palliation for the vast majority of patients. Oncolytic viral therapy represents a promising novel therapeutic modality that has achieved tumor regression in several preclinical and clinical models. Evidence further suggests that locoregional viral administration may improve viral efficacy while minimizing toxicity. This study will review the theories behind hepatic arterial infusion of oncolytic virus, as well as herpes viral design, preclinical data, and clinical progress in regional liver therapy using oncolytic virus to treat hepatic colorectal carcinoma metastases. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | treatment response; unclassified drug; gene deletion; clinical trial; fatigue; fluorouracil; diarrhea; drug efficacy; drug safety; monotherapy; nonhuman; side effect; antineoplastic agents; clinical trials as topic; liver neoplasms; outcome assessment; antineoplastic agent; colorectal cancer; animals; metastasis; pain; nausea; carcinoembryonic antigen; combination chemotherapy; antineoplastic activity; continuous infusion; viral gene delivery system; chill; colorectal carcinoma; drug fever; colorectal neoplasms; drug induced headache; liver metastasis; folinic acid; simplexvirus; oncolytic viruses; oncolytic virotherapy; atelectasis; thymidine kinase; virus infection; virus replication; gene insertion; herpes simplex virus 1; nv 1020; hepatic artery; virus protein; major histocompatibility antigen class 1; virus vector; nv 1023; onyx 015; g 207; hrr 3; nv 1034; protein u39; ribonucleotide reductase; colorectal metastasis; evolutionary developmental biology; morris hepatoma; shivering |
| Journal Title: | Seminars in Oncology |
| Volume: | 37 |
| Issue: | 2 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-04-01 |
| Start Page: | 160 |
| End Page: | 169 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2010.03.001 |
| PUBMED: | 20494708 |
| PROVIDER: | scopus |
| PMCID: | PMC3266826 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: SOLGA" - "Source: Scopus" |
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