Intracranial Hemorrhage in patients with cancer Journal Article
| Authors: | Velander, A. J.; De Angelis, L. M.; Navi, B. B. |
| Article Title: | Intracranial Hemorrhage in patients with cancer |
| Abstract: | Intracranial hemorrhage (ICH) is a common neurological emergency in patients with cancer, typically occurring late in the disease course, although it occasionally heralds the cancer diagnosis. ICH in these patients often occurs from unique mechanisms, especially intratumoral hemorrhage or coagulopathy, whereas hypertensive hemorrhage is rare. Lung, melanoma, breast, and glioblastoma multiforme are the most commonly associated solid tumors, partly because of their ubiquity and frequent brain involvement, whereas leukemia is the most commonly associated hematological cancer. Patients typically present with focal neurological deficits, headache, and encephalopathy, and their initial diagnostic evaluation and management should follow standard guidelines, although steroids and/or surgical resection should be strongly considered in those with intratumoral hemorrhage. Short-Term outcomes are comparable to ICH in the community, whereas long-Term outcomes are generally poor, corresponding to the prognosis of the underlying cancer. This review focuses on the recent advances and special considerations in cancer-related intracranial hemorrhage. © Springer Science+Business Media, LLC 2012. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; clinical feature; cancer localization; bevacizumab; sunitinib; cancer risk; hypertension; cancer patient; cancer radiotherapy; nuclear magnetic resonance imaging; outcome assessment; glioma; brain neoplasms; cancer incidence; neoplasm; neoplasms; disease association; bleeding; steroid; kidney carcinoma; cancer mortality; cardiovascular risk; stroke; thromboembolism; glioblastoma; brain metastasis; malignant neoplastic disease; malignancy; brain hemorrhage; tumor bleeding; computed tomographic angiography; anticoagulant agent; subarachnoid hemorrhage; recombinant blood clotting factor 7a; intracranial hemorrhages; intracranial hemorrhage; intracerebral hemorrhage; cancer prognosis; blood coagulation disorders; hemorrhagic stroke; idiopathic intraparenchymal hemorrhage; mechanical thrombectomy |
| Journal Title: | Current Atherosclerosis Reports |
| Volume: | 14 |
| Issue: | 4 |
| ISSN: | 1523-3804 |
| Publisher: | Current Medicine Group |
| Date Published: | 2012-08-01 |
| Start Page: | 373 |
| End Page: | 381 |
| Language: | English |
| DOI: | 10.1007/s11883-012-0250-3 |
| PROVIDER: | scopus |
| PUBMED: | 22528522 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 January 2013" - "CODEN: CARUC" - "Source: Scopus" |
