Head and Neck Sarcomas. Epidemiology, Pathology, and Management Journal Article
| Authors: | O'neill, J. P.; Bilsky, M. H.; Kraus, D. |
| Article Title: | Head and Neck Sarcomas. Epidemiology, Pathology, and Management |
| Abstract: | Sarcomas of the head, neck, and skull base represent a heterogeneous group of tumors with distinct prognostic features. There have been significant improvements in characterizing these sarcomas using traditional morphologic assessments and more recent immunohistochemical analysis. Surgery is the mainstay of treatment followed by radiation therapy. Treatment modalities have changed in select pediatric sarcomas, for which new chemotherapeutic combinations have improved survival statistics. The high rate of distant failure emphasizes the need for novel systemic and directed molecular therapies. Tumor grade, size, and margin status are key factors in survival. © 2013 Elsevier Inc. |
| Keywords: | osteosarcoma; protein kinase b; cancer chemotherapy; cancer survival; protein expression; cancer surgery; unclassified drug; overall survival; histopathology; review; cancer localization; cisplatin; doxorubicin; cancer risk; multimodality cancer therapy; disease marker; cancer radiotherapy; chemotherapy; methotrexate; temozolomide; topotecan; cancer staging; drug megadose; lymph node metastasis; cancer grading; ki 67 antigen; radiation; differential diagnosis; prevalence; transcription factor; cyclophosphamide; vincristine; angiosarcoma; immunoreactivity; ifosfamide; risk assessment; carcinogenesis; cixutumumab; irinotecan; sarcoma; cancer invasion; vasculotropin c; fibrosarcoma; head and neck cancer; folinic acid; cancer size; vasculotropin a; dactinomycin; initiation factor 4e binding protein 1; surgery; cancer control; malignant fibrous histiocytoma; rhabdomyosarcoma; synovial sarcoma; grade; chondrosarcoma; margins; cancer morphology; liposarcoma; cd31 antigen; vimentin; size; alpha 1 antichymotrypsin; chromosome deletion 13; cancer prognosis; protein elf4e |
| Journal Title: | Neurosurgery Clinics of North America |
| Volume: | 24 |
| Issue: | 1 |
| ISSN: | 1042-3680 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2013-01-01 |
| Start Page: | 67 |
| End Page: | 78 |
| Language: | English |
| DOI: | 10.1016/j.nec.2012.08.010 |
| PROVIDER: | scopus |
| PUBMED: | 23174358 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: NCNAF" - "Source: Scopus" |
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