Chemistry as an expanding resource in protein science: Fully synthetic and fully active human parathyroid hormone-related protein (1 - 141) Journal Article

   


Authors: Li, J.; Dong, S.; Townsend, S. D.; Dean, T.; Gardella, T. J.; Danishefsky, S. J.
Article Title: Chemistry as an expanding resource in protein science: Fully synthetic and fully active human parathyroid hormone-related protein (1 - 141)
Abstract: The convergent synthesis of human parathyroid hormone-related protein (hPTHrP, see scheme) has been accomplished through iterative peptide ligations followed by global metal-free dethiylation. The biological activity of synthetic PTHrP has been demonstrated. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords: proteins; biosynthesis; biological activity; bioactivity; ligation; surgical equipment; convergent synthesis; solid-phase synthesis; solid phase synthesis; dethiylation; protein science
Journal Title: Angewandte Chemie - International Edition
Volume: 51
Issue: 49
ISSN: 1433-7851
Publisher: Wiley Blackwell  
Date Published: 2012-12-03
Start Page: 12263
End Page: 12267
Language: English
DOI: 10.1002/anie.201207603
PROVIDER: scopus
PUBMED: 23124999
PMCID: PMC3739057
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84870544133&partnerID=40&md5=ac29a1ff70888d6ef081ddf2bedf9738
Notes: --- - "Export Date: 2 January 2013" - "CODEN: ACIEF" - "Source: Scopus"
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MSK Authors
  1. Samuel J Danishefsky
    539 Danishefsky
  2. Suwei Dong
    8 Dong
  3. Jianfeng Li
    2 Li
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