Annotating MYC status with (89)Zr-transferrin imaging Journal Article
| Authors: | Holland, J. P.; Evans, M. J.; Rice, S. L.; Wongvipat, J.; Sawyers, C. L.; Lewis, J. S. |
| Article Title: | Annotating MYC status with (89)Zr-transferrin imaging |
| Abstract: | A noninvasive technology that quantitatively measures the activity of oncogenic signaling pathways could have a broad impact on cancer diagnosis and treatment with targeted therapies. Here we describe the development of 89Zr-desferrioxamine-labeled transferrin (89Zr- transferrin), a new positron emission tomography (PET) radiotracer that binds the transferrin receptor 1 (TFRC, CD71) with high avidity. The use of 89Zr-transferrin produces high-contrast PET images that quantitatively reflect treatment-induced changes in MYC-regulated TFRC expression in a MYC-driven prostate cancer xenograft model. Moreover, 89Zr-transferrin imaging can detect the in situ development of prostate cancer in a transgenic MYC prostate cancer model, as well as in prostatic intraepithelial neoplasia (PIN) before histological or anatomic evidence of invasive cancer. These preclinical data establish 89Zr-transferrin as a sensitive tool for noninvasive measurement of oncogene-driven TFRC expression in prostate and potentially other cancers, with prospective near-term clinical application. © 2012 Nature America, Inc. All rights reserved. |
| Keywords: | controlled study; protein expression; nonhuman; positron emission tomography; radiopharmaceuticals; binding affinity; mouse; animals; mice; animal experiment; animal model; tumor xenograft; cancer model; transgenic mouse; mice, transgenic; prostate cancer; prostatic neoplasms; myc protein; positron-emission tomography; transplantation, heterologous; prostatic intraepithelial neoplasia; proto-oncogene proteins c-myc; radioisotopes; non invasive procedure; zirconium; deferoxamine; transferrin; receptors, transferrin; cd71 antigen |
| Journal Title: | Nature Medicine |
| Volume: | 18 |
| Issue: | 10 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-10-01 |
| Start Page: | 1586 |
| End Page: | 1591 |
| Language: | English |
| DOI: | 10.1038/nm.2935 |
| PROVIDER: | scopus |
| PMCID: | PMC3521603 |
| PUBMED: | 23001181 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: NAMEF" - "Source: Scopus" |
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