Annotating MYC status with (89)Zr-transferrin imaging Journal Article


Authors: Holland, J. P.; Evans, M. J.; Rice, S. L.; Wongvipat, J.; Sawyers, C. L.; Lewis, J. S.
Article Title: Annotating MYC status with (89)Zr-transferrin imaging
Abstract: A noninvasive technology that quantitatively measures the activity of oncogenic signaling pathways could have a broad impact on cancer diagnosis and treatment with targeted therapies. Here we describe the development of 89Zr-desferrioxamine-labeled transferrin (89Zr- transferrin), a new positron emission tomography (PET) radiotracer that binds the transferrin receptor 1 (TFRC, CD71) with high avidity. The use of 89Zr-transferrin produces high-contrast PET images that quantitatively reflect treatment-induced changes in MYC-regulated TFRC expression in a MYC-driven prostate cancer xenograft model. Moreover, 89Zr-transferrin imaging can detect the in situ development of prostate cancer in a transgenic MYC prostate cancer model, as well as in prostatic intraepithelial neoplasia (PIN) before histological or anatomic evidence of invasive cancer. These preclinical data establish 89Zr-transferrin as a sensitive tool for noninvasive measurement of oncogene-driven TFRC expression in prostate and potentially other cancers, with prospective near-term clinical application. © 2012 Nature America, Inc. All rights reserved.
Keywords: controlled study; protein expression; nonhuman; positron emission tomography; radiopharmaceuticals; binding affinity; mouse; animals; mice; animal experiment; animal model; tumor xenograft; cancer model; transgenic mouse; mice, transgenic; prostate cancer; prostatic neoplasms; myc protein; positron-emission tomography; transplantation, heterologous; prostatic intraepithelial neoplasia; proto-oncogene proteins c-myc; radioisotopes; non invasive procedure; zirconium; deferoxamine; transferrin; receptors, transferrin; cd71 antigen
Journal Title: Nature Medicine
Volume: 18
Issue: 10
ISSN: 1078-8956
Publisher: Nature Publishing Group  
Date Published: 2012-10-01
Start Page: 1586
End Page: 1591
Language: English
DOI: 10.1038/nm.2935
PROVIDER: scopus
PMCID: PMC3521603
PUBMED: 23001181
DOI/URL:
Notes: --- - "Export Date: 2 January 2013" - "CODEN: NAMEF" - "Source: Scopus"
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MSK Authors
  1. Charles L Sawyers
    225 Sawyers
  2. Jason Philip Holland
    31 Holland
  3. Samuel Rice
    14 Rice
  4. Michael John Evans
    22 Evans
  5. Jason S Lewis
    456 Lewis