What is the impact, present and future, of novel targeted agents in acute lymphoblastic leukemia? Journal Article
| Author: | Douer, D. |
| Article Title: | What is the impact, present and future, of novel targeted agents in acute lymphoblastic leukemia? |
| Abstract: | The absence of a standard of care for adults with acute lymphoblastic leukemia (ALL), the inadequate outcome of all adult regimens, and the lack of improvement in treatment outcomes over the past decades suggest a critical need for new approaches to treating adults with this disease. Several new strategies are now being considered, including the use of novel targeted agents alone and in combination with other chemotherapeutic drugs. This paper discusses several of these approaches and their impact on overall outcome. © 2012 Elsevier Ltd. All rights reserved. |
| Keywords: | cancer survival; event free survival; protein expression; overall survival; prednisone; review; cancer combination chemotherapy; treatment duration; cytarabine; rituximab; drug megadose; outcome assessment; t lymphocyte; gene; cell survival; imatinib; cell maturation; cyclophosphamide; vincristine; clinical protocol; hematopoietic stem cell transplantation; continuous infusion; dasatinib; acute lymphoblastic leukemia; b lymphocyte; mitoxantrone; daunorubicin; asparaginase; cytokine production; bcr abl protein; tyrosine kinase inhibitor; leukemia relapse; antibody; targeted agents; chromosome 11q; notch1 receptor; gemtuzumab ozogamicin; mercaptopurine; leukemia remission; cd22 antigen; recurrence free survival; randomized controlled trial (topic); clinical trial (topic); molecularly targeted therapy; phase 2 clinical trial (topic); phase 3 clinical trial (topic); steroids; epratuzumab; all; vein occlusion; mixed lineage leukemia protein; intrathecal methotrexate; cd20 antibody; calicheamicin; blinatumomab; moxetumomab pasudotox; cd19 antibody; berlin-frankfurt- munster (bfm); chimeric antigen receptor (car); hypercvad; minimal residual disease (mrd); nonmyelosuppresive; pediatric inspired |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 25 |
| Issue: | 4 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-12-01 |
| Start Page: | 453 |
| End Page: | 464 |
| Language: | English |
| DOI: | 10.1016/j.beha.2012.10.008 |
| PROVIDER: | scopus |
| PUBMED: | 23200542 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: BPRCA" - "Source: Scopus" |
