Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis Journal Article

   

Authors:	Diab, A.; Zickl, L.; Abdel-Wahab, O.; Jhanwar, S.; Gulam, M. A.; Panageas, K. S.; Patel, J. P.; Jurcic, J.; Maslak, P.; Paietta, E.; Mangan, J. K.; Carroll, M.; Fernandez, H. F.; Teruya-Feldstein, J.; Luger, S. M.; Douer, D.; Litzow, M. R.; Lazarus, H. M.; Rowe, J. M.; Levine, R. L.; Tallman, M. S.
Article Title:	Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis
Abstract:	Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, cytomorphologic, immunophenotypic and cytogenetic features. Half of the patients had extramedullary disease, most commonly leukemia cutis, which often preceded bone marrow involvement and six had therapy-related AML. Patients with t(8;16) AML commonly present with clinical and pathological features that mimic APL, with promyelocytes and promyeloblast-like cells and coagulopathy in most patients. Several patients also presented with marrow histiocytes with hemophagocytosis and erythrophagocytosis. Comprehensive molecular analysis for co-occurring genetic alterations revealed a somatic mutation in RUNX1 in 1 of 6 t(8;16) patients with no known AML mutation in the remaining five t(8;16) patients. This suggests that the t(8;16) translocation could be sufficient to induce hematopoietic cell transformation to AML without acquiring other genetic alteration. These data further support classifying t(8;16) AML as a clinically and molecularly defined subtype of AML marked by characteristic clinical and cytomorphologic features that mimic APL, and is associated with very poor survival. © 2012 Elsevier Ltd.
Keywords:	leukemia; aml; apl; t(8; 16); therapy-related aml
Journal Title:	Leukemia Research
Volume:	37
Issue:	1
ISSN:	0145-2126
Publisher:	Elsevier Ltd
Date Published:	2013-01-01
Start Page:	32
End Page:	36
Language:	English
DOI:	10.1016/j.leukres.2012.08.025
PROVIDER:	scopus
PUBMED:	23102703
PMCID:	PMC5382928
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84870950950&partnerID=40&md5=c1e59fd633f5fa7a4bb20d89e1205109
Notes:	--- - "Export Date: 2 January 2013" - "CODEN: LERED" - "Source: Scopus"

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