Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis Journal Article


Authors: Diab, A.; Zickl, L.; Abdel-Wahab, O.; Jhanwar, S.; Gulam, M. A.; Panageas, K. S.; Patel, J. P.; Jurcic, J.; Maslak, P.; Paietta, E.; Mangan, J. K.; Carroll, M.; Fernandez, H. F.; Teruya-Feldstein, J.; Luger, S. M.; Douer, D.; Litzow, M. R.; Lazarus, H. M.; Rowe, J. M.; Levine, R. L.; Tallman, M. S.
Article Title: Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis
Abstract: Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, cytomorphologic, immunophenotypic and cytogenetic features. Half of the patients had extramedullary disease, most commonly leukemia cutis, which often preceded bone marrow involvement and six had therapy-related AML. Patients with t(8;16) AML commonly present with clinical and pathological features that mimic APL, with promyelocytes and promyeloblast-like cells and coagulopathy in most patients. Several patients also presented with marrow histiocytes with hemophagocytosis and erythrophagocytosis. Comprehensive molecular analysis for co-occurring genetic alterations revealed a somatic mutation in RUNX1 in 1 of 6 t(8;16) patients with no known AML mutation in the remaining five t(8;16) patients. This suggests that the t(8;16) translocation could be sufficient to induce hematopoietic cell transformation to AML without acquiring other genetic alteration. These data further support classifying t(8;16) AML as a clinically and molecularly defined subtype of AML marked by characteristic clinical and cytomorphologic features that mimic APL, and is associated with very poor survival. © 2012 Elsevier Ltd.
Keywords: leukemia; aml; apl; t(8; 16); therapy-related aml
Journal Title: Leukemia Research
Volume: 37
Issue: 1
ISSN: 0145-2126
Publisher: Pergamon-Elsevier Science Ltd  
Date Published: 2013-01-01
Start Page: 32
End Page: 36
Language: English
DOI: 10.1016/j.leukres.2012.08.025
PROVIDER: scopus
PUBMED: 23102703
PMCID: PMC5382928
DOI/URL:
Notes: --- - "Export Date: 2 January 2013" - "CODEN: LERED" - "Source: Scopus"
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MSK Authors
  1. Julie T Feldstein
    288 Feldstein
  2. Martin Stuart Tallman
    443 Tallman
  3. Joseph G Jurcic
    127 Jurcic
  4. Adi Diab
    25 Diab
  5. Ross Levine
    492 Levine
  6. Katherine S Panageas
    331 Panageas
  7. Peter Maslak
    169 Maslak
  8. Suresh C Jhanwar
    220 Jhanwar
  9. Dan Douer
    81 Douer
  10. Jay Prakash Patel
    53 Patel