Radiation therapy and hearing loss Journal Article
| Authors: | Bhandare, N.; Jackson, A.; Eisbruch, A.; Pan, C. C.; Flickinger, J. C.; Antonelli, P.; Mendenhall, W. M. |
| Article Title: | Radiation therapy and hearing loss |
| Abstract: | A review of literature on the development of sensorineural hearing loss after high-dose radiation therapy for head-and-neck tumors and stereotactic radiosurgery or fractionated stereotactic radiotherapy for the treatment of vestibular schwannoma is presented. Because of the small volume of the cochlea a dose-volume analysis is not feasible. Instead, the current literature on the effect of the mean dose received by the cochlea and other treatment- and patient-related factors on outcome are evaluated. Based on the data, a specific threshold dose to cochlea for sensorineural hearing loss cannot be determined; therefore, dose-prescription limits are suggested. A standard for evaluating radiation therapy-associated ototoxicity as well as a detailed approach for scoring toxicity is presented. © 2010 Elsevier Inc. All rights reserved. |
| Keywords: | treatment outcome; cisplatin; cancer radiotherapy; radiation dose; outcome assessment; antineoplastic agent; models, biological; tumor volume; radiotherapy dosage; radiotherapy; radiation injury; mathematical model; head and neck cancer; head and neck neoplasms; radiation dose fractionation; radiosurgery; scoring system; radiation therapy; ear; stereotactic radiosurgery; organ size; hearing loss; neurilemoma; ototoxicity; vestibular schwannoma; neuroma, acoustic; auditory; quantec; sensorineural hearing loss; dose-volume analysis; fractionated stereotactic radiotherapy; head-and-neck tumor; high dose; mean dose; threshold dose; audition; audiometry; auditory threshold; bone conduction; cochlea; otitis media; perception deafness; hearing loss, sensorineural |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 76 |
| Issue: | 3 Suppl. |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-03-01 |
| Start Page: | S50 |
| End Page: | S57 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2009.04.096 |
| PUBMED: | 20171518 |
| PROVIDER: | scopus |
| PMCID: | PMC3319461 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: IOBPD" - "Source: Scopus" |
