Metabolic syndromes and malignant transformation: Where the twain shall meet Journal Article

  


Authors: Bhagwat, N.; Levine, R. L.
Article Title: Metabolic syndromes and malignant transformation: Where the twain shall meet
Abstract: Recurrent somatic mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes that result in the accumulation of D-2-hydroxyglutarate (D-2-HG) have been identified in malignant gliomas and in acute myeloid leukemia (AML). However, the function of this metabolite in normal and malignant tissues remains uncertain. A report in the current issue of Science describes a germline IDH2 mutation in a subset of patients with a rare metabolic disorder - D-2-hydroxyglutaric aciduria - that is similar to mutations seen in cancer patients. These observations further elucidate the effects of IDH mutations on normal and malignant cells.
Keywords: unclassified drug; acute granulocytic leukemia; somatic mutation; genetics; mutation; leukemia, myeloid, acute; clinical feature; pathogenesis; review; nonhuman; cancer patient; glioma; metabolism; amino acid substitution; genetic association; pathology; mutational analysis; heterozygote; cell transformation, neoplastic; enzyme analysis; cell transformation; glioblastoma; malignant neoplastic disease; metabolic syndrome x; malignant transformation; enzyme structure; metabolic disorder; enzyme mechanism; isocitrate dehydrogenase; molecular pathology; glutarates; 2 hydroxyglutaric acid; 2 oxoglutaric acid; isocitrate dehydrogenase 1; isocitrate dehydrogenase isoenzyme; alpha-hydroxyglutarate; glutaric acid derivative; 2 hydroxyglutaric aciduria; autosomal recessive inheritance; inborn error of metabolism; metabolism, inborn errors
Journal Title: Science Translational Medicine
Volume: 2
Issue: 54
ISSN: 1946-6234
Publisher: American Association for the Advancement of Science  
Date Published: 2010-10-20
Start Page: 54ps50
Language: English
DOI: 10.1126/scitranslmed.3001669
PUBMED: 20962328
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77958580680&partnerID=40&md5=eaf4162a53b4a150c6a4dd47c7161ed8
Notes: --- - "Export Date: 20 April 2011" - "Art. No.: 54ps50" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Neha Bhagwat
    22 Bhagwat
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