Tregs served sunny-side up Journal Article
| Authors: | Betts, B. C.; Young, J. W. |
| Article Title: | Tregs served sunny-side up |
| Abstract: | In this issue of Blood, Bastien and colleagues demonstrate that photopheresis purges donor T cells proliferating against host alloantigens in patients with GVHD after HSCT.1 Photodepletion of these alloreactive lymphocytes concomitantly preserves and expands Tregs, which when reinfused into patients with treatment-refractory chronic GVHD, survive in vivo and correlate with positive clinical responses. |
| Keywords: | unclassified drug; note; ultraviolet radiation; transcription factor foxp3; lymphocyte proliferation; cell survival; gene expression; hematopoietic stem cell transplantation; in vivo study; regulatory t lymphocyte; graft versus host reaction; alloantigen; cell expansion; multidrug resistance protein 1; photosensitizing agent; th 9402; light exposure; puva |
| Journal Title: | Blood |
| Volume: | 116 |
| Issue: | 23 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2010-12-02 |
| Start Page: | 4736 |
| End Page: | 4737 |
| Language: | English |
| DOI: | 10.1182/blood-2010-09-307546 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: BLOOA" - "Source: Scopus" |
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