A phase i study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors Journal Article
| Authors: | Wang-Gillam, A.; Tew, W. P.; Rothenberg, M. L.; Dupont, J.; Cooper, W.; Sternas, L.; Buzenet, G.; Sosman, J. A.; Spriggs, D. R.; Lockhart, A. C. |
| Article Title: | A phase i study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors |
| Abstract: | Summary: Targeting angiogenesis is a valid anti-cancer strategy. Aflibercept is designed to sequester circulating vascular endothelial growth factor (VEGF) by preventing VEGF from binding to its receptors. This phase I study was to evaluate a new formulation of subcutaneously administered aflibercept in patients with advanced solid tumors. Here we report our experience with the toxicity, pharmacokinetic profile and efficacy of the new 100 mg/mL subcutaneous (SC) formulation of aflibercept administered at a dose of at 4 mg/kg every 2 weeks. © 2011 The Author(s). |
| Keywords: | adult; clinical article; aged; constipation; fatigue; angiogenesis inhibitor; advanced cancer; diarrhea; drug dose reduction; drug efficacy; drug withdrawal; hypertension; side effect; solid tumor; cancer patient; anorexia; nausea; myalgia; drug dosage form comparison; cohort analysis; abdominal pain; arthralgia; backache; coughing; dyspnea; nail disease; drug induced headache; aflibercept; muscle weakness; peripheral edema; erythema; limb pain; maximum plasma concentration; drug absorption; drug blood level; phase 1 clinical trial; drug half life; connective tissue disease; glossodynia; dry skin; proteinuria; musculoskeletal disease; satiety; drug formulation; mouth pain; nose obstruction; sore throat; joint stiffness; dysphonia; musculoskeletal pain; phase i study; subcutaneously administration; dry nose; spasticity |
| Journal Title: | Investigational New Drugs |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 0167-6997 |
| Publisher: | Springer |
| Date Published: | 2012-10-01 |
| Start Page: | 1958 |
| End Page: | 1961 |
| Language: | English |
| DOI: | 10.1007/s10637-011-9753-y |
| PROVIDER: | scopus |
| PMCID: | PMC3432791 |
| PUBMED: | 22002018 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: INNDD" - "Source: Scopus" |
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