Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium Journal Article
| Authors: | Mascarenhas, J.; Heaney, M. L.; Najfeld, V.; Hexner, E.; Abdel-Wahab, O.; Rampal, R.; Ravandi, F.; Petersen, B.; Roboz, G.; Feldman, E.; Podoltsev, N.; Douer, D.; Levine, R.; Tallman, M.; Hoffman, R. |
| Article Title: | Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium |
| Abstract: | Leukemic transformation (LT) of a myeloproliferative neoplasm (MPN) is associated with a dismal prognosis and no medical therapies have shown a survival improvement in patients with MPN in blast phase (MPN-BP). Effective therapies for the treatment of MPN-BP are a serious unmet need. Consensus response criteria do not exist for the treatment of patients with MPN-BP and this is necessary for the uniformed reporting of treatment response in clinical trials. We have identified relevant MPN and MPN-BP features in order to define treatment response categories that reflect hematological, clinical, pathological, cytogenetic and molecular changes after therapeutic intervention. We plan to validate these proposed response criteria within multi-centered clinical trials. © 2012 Elsevier Ltd. |
| Keywords: | treatment outcome; treatment response; myeloproliferative disorders; acute granulocytic leukemia; gene mutation; leukemia, myeloid, acute; clinical trial; disease course; histopathology; clinical trials as topic; molecular genetics; gene; bone marrow; spleen; clinical assessment; cytogenetics; hematopoietic stem cell transplantation; validation study; bone marrow biopsy; blood analysis; transplantation conditioning; blood cells; malignant transformation; response criteria; karyotyping; myeloproliferative neoplasm; genetic markers; clinical trial (topic); blast crisis; myeloablative agonists; multicenter study (topic); acute myeloid leukemia; jak2 gene; blast phase; leukemic transformation; myeloproliferative neoplasm in blast phase |
| Journal Title: | Leukemia Research |
| Volume: | 36 |
| Issue: | 12 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2012-12-01 |
| Start Page: | 1500 |
| End Page: | 1504 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2012.08.013 |
| PROVIDER: | scopus |
| PUBMED: | 22938832 |
| PMCID: | PMC4114151 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 December 2012" - "CODEN: LERED" - "Source: Scopus" |
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